Research map: Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation

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  1. Highly accurate protein structure prediction with AlphaFold · John Jumper · 2021 · 47614 citations · Cited by this paper
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  25. nmb , a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts · Marian A. J. Weterman · 1995 · 265 citations · Cited by this paper
  26. Gpnmb Is Induced in Macrophages by IFN-γ and Lipopolysaccharide and Acts as a Feedback Regulator of Proinflammatory Responses · Vera M. Ripoll · 2007 · 246 citations · Cited by this paper
  27. ADAM10 Releases a Soluble Form of the GPNMB/Osteoactivin Extracellular Domain with Angiogenic Properties · April A. N. Rose · 2010 · 229 citations · Cited by this paper
  28. Glycoprotein Nonmetastatic B Is an Independent Prognostic Indicator of Recurrence and a Novel Therapeutic Target in Breast Cancer · April A. N. Rose · 2010 · 197 citations · Cited by this paper
  29. EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB–Expressing Breast Cancer · Denise Aysel Yardley · 2015 · 195 citations · Cited by this paper
  30. Stepping forward in antibody-drug conjugate development · Yiming Jin · 2021 · 192 citations · Cited by this paper
  31. Autophagy in cancer development, immune evasion, and drug resistance · Xuegang Niu · 2024 · 186 citations · Cited by this paper
  32. Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Glioblastoma Multiforme · Chien-Tsun Kuan · 2006 · 184 citations · Cited by this paper
  33. Molecular Cloning of a Dendritic Cell-associated Transmembrane Protein, DC-HIL, That Promotes RGD-dependent Adhesion of Endothelial Cells through Recognition of Heparan Sulfate Proteoglycans · Sojin Shikano · 2001 · 169 citations · Cited by this paper
  34. LAMPs: Shedding light on cancer biology · Federica Alessandrini · 2017 · 168 citations · Cited by this paper
  35. Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function · SAIEDAT S ABDEL-MAGID · 2008 · 145 citations · Cited by this paper
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  38. The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33 · Manuela Liguori · 2020 · 131 citations · Cited by this paper
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