Research map: Senotherapeutics for Knee Osteoarthritis

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  1. The serial cultivation of human diploid cell strains · Leonard Hayflick · 1961 · 8556 citations · Cited by this paper
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  17. Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors · David T. Felson · 2000 · 2553 citations · Cited by this paper
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  19. The mechanisms of action of metformin · Graham Rena · 2017 · 2317 citations · Cited by this paper
  20. Cellular Senescence in Skeletal Muscle Aging · 2026 · Related
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  22. ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor · Christin Tse · 2008 · 2004 citations · Cited by this paper
  23. Cyclin-dependent kinases · Marcos Malumbres · 2014 · 1736 citations · Cited by this paper
  24. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype · Ruchi Kumari · 2021 · 1666 citations · Cited by this paper
  25. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment · Ok Hee Jeon · 2017 · 1550 citations · Cited by this paper
  26. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging · Marjolein P. Baar · 2017 · 1482 citations · Cited by this paper
  27. Reversal of human cellular senescence: roles of the p53 and p16 pathways · Christian M. Beausejour · 2003 · 1472 citations · Cited by this paper
  28. Cell cycle regulation: p53-p21-RB signaling · Kurt Engeland · 2022 · 1340 citations · Cited by this paper
  29. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized · Mark F. van Delft · 2006 · 1240 citations · Cited by this paper
  30. Osteoarthritis: pathogenic signaling pathways and therapeutic targets · Qing Yao · 2023 · 1170 citations · Cited by this paper
  31. Cellular senescence: the good, the bad and the unknown · Weijun Huang · 2022 · 1169 citations · Cited by this paper
  32. A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy · Clemens A. Schmitt · 2002 · 1055 citations · Cited by this paper
  33. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL · Reut Yosef · 2016 · 1052 citations · Cited by this paper
  34. The epidemiology of osteoarthritis · Victoria Johnson · 2014 · 1040 citations · Cited by this paper
  35. Epidemiology of osteoarthritis: literature update · Ernest R. Vina · 2017 · 1033 citations · Cited by this paper
  36. Unmasking Transcriptional Heterogeneity in Senescent Cells · Alejandra Hernandez‐Segura · 2017 · 967 citations · Cited by this paper
  37. Senescence and apoptosis: dueling or complementary cell fates? · Bennett G. Childs · 2014 · 927 citations · Cited by this paper
  38. The surface of articular cartilage contains a progenitor cell population · Gary P. Dowthwaite · 2004 · 920 citations · Cited by this paper
  39. Cellular senescence and tumor suppressor gene p16 · Hani M. Rayess · 2011 · 846 citations · Cited by this paper

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