Research map: Orforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling

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Papers in this map

  1. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes · Eduardo Bossone · 2020 · 490 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
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  13. Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study · Juan P. Frías · 2023 · 180 citations · Cited by this paper
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  15. Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections · Abhijit Chakraborty · 2023 · 161 citations · Cited by this paper
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  17. Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a–JNK Signaling · Rosa Bretón‐Romero · 2016 · 123 citations · Cited by this paper
  18. Quercetin induces ferroptosis in ovarian cancer by suppressing the NRF2/HO‑1/GPX4 axis and increasing the efficacy of cisplatin · 2026 · Related
  19. Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders · Pooja M. Bhatt · 2014 · 115 citations · Cited by this paper
  20. Resistin induces cardiac fibroblast-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun signaling · Rajvir Singh · 2021 · 91 citations · Cited by this paper
  21. Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans · Yoshito Yamashiro · 2018 · 81 citations · Cited by this paper
  22. Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells · J. Gregg · 2011 · 80 citations · Cited by this paper
  23. GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function · Nour Zaïmia · 2023 · 74 citations · Cited by this paper
  24. Phosphodiesterase-8A binds to and regulates Raf-1 kinase · Kim M. Brown · 2013 · 63 citations · Cited by this paper
  25. Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5 · Ni Zhu · 2023 · 57 citations · Cited by this paper
  26. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial · Deborah Bade Horn · 2025 · 57 citations · Cited by this paper
  27. Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling · Jolanta Chmielowiec · 2022 · 48 citations · Cited by this paper
  28. Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer · Yunfei Lu · 2025 · 40 citations · Cited by this paper
  29. Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration · Dandan Liu · 2024 · 31 citations · Cited by this paper
  30. Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE -/- mice · Keyin Zhang · 2024 · 28 citations · Cited by this paper
  31. Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches · Manizheh Azhdari · 2024 · 28 citations · Cited by this paper
  32. Efficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial · Julio Rosenstock · 2026 · 27 citations · Cited by this paper
  33. Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice · Seung Jae Shin · 2020 · 25 citations · Cited by this paper
  34. Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1–JNK–DRP1 pathway · Guohua Lou · 2021 · 22 citations · Cited by this paper
  35. Ncf1 knockout in smooth muscle cells exacerbates angiotensin II–induced aortic aneurysm and dissection by activating the STING pathway · Hao Liu · 2024 · 22 citations · Cited by this paper
  36. Genomic Editing of a Pathogenic Sequence Variant in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice · Qianqian Ding · 2025 · 16 citations · Cited by this paper
  37. Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway · Hui Zhou · 2025 · 11 citations · Cited by this paper
  38. Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements · Abhineet R. Ram · 2025 · 10 citations · Cited by this paper
  39. Targeting WNT5A noncanonical signaling attenuates renal fibrosis progression in acute kidney injury · Sijie Gu · 2025 · 10 citations · Cited by this paper

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