Research map: Estrogen’s master switch: NFκB-NLRP3, SIRT1-HMGB1, and TLR4 triad tamed for brain rescue in ageing and neurodegeneration

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  1. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets · Chao Gao · 2023 · 1587 citations · Cited by this paper
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  5. Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines · Glenda E. Gillies · 2010 · 743 citations · Cited by this paper
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  15. Estrogens, Neuroinflammation, and Neurodegeneration · Alessandro Maria Villa · 2016 · 432 citations · Cited by this paper
  16. Developmental-vitamin D deficiency epigenetically regulates cell cycling genes in the embryonic mesencephalon via DNA methylation · 2026 · Related
  17. Transcription factor cross-talk: the estrogen receptor and NF-κB · Demetrios Kalaitzidis · 2005 · 389 citations · Cited by this paper
  18. New insights into prostate cancer progression: A focus on vitamin D signaling · 2026 · Related
  19. Energy metabolism in health and diseases · Hui Liu · 2025 · 387 citations · Cited by this paper
  20. Tissue-Predominant Estrogen Metabolic Remodeling in Adenomyosis Revealed by LC-MS/MS Profiling · 2026 · Related
  21. Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol · Elisabetta Vegeto · 2003 · 384 citations · Cited by this paper
  22. Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases · Elisabetta Vegeto · 2008 · 363 citations · Cited by this paper
  23. Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females · Anne Almey · 2015 · 318 citations · Cited by this paper
  24. NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice · Yongjun Xu · 2016 · 309 citations · Cited by this paper
  25. The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease · Micheline McCarthy · 2020 · 258 citations · Cited by this paper
  26. Estrogen synthesis in the brain—Role in synaptic plasticity and memory · Yasushi Hojo · 2008 · 215 citations · Cited by this paper
  27. The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders · Wu Jeong Hwang · 2020 · 215 citations · Cited by this paper
  28. Inhibition of the NLRP3 inflammasome prevents ovarian aging · José Manuel Navarro-Pando · 2021 · 194 citations · Cited by this paper
  29. The Effect of Estrogen Replacement Therapy on Alzheimer's Disease and Parkinson's Disease in Postmenopausal Women: A Meta-Analysis · Yujia Song · 2020 · 173 citations · Cited by this paper
  30. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors α and β · Shotaro Suzuki · 2006 · 172 citations · Cited by this paper
  31. AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy · Junyang Chen · 2025 · 171 citations · Cited by this paper
  32. The Endogenous Estrogen Status Regulates Microglia Reactivity in Animal Models of Neuroinflammation · Elisabetta Vegeto · 2006 · 170 citations · Cited by this paper
  33. Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases · Simone Patergnani · 2021 · 165 citations · Cited by this paper
  34. Estrogen Enhances Uptake of Amyloid β‐Protein by Microglia Derived from the Human Cortex · Rena Li · 2000 · 162 citations · Cited by this paper
  35. The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful? · Felipe A. Bustamante-Barrientos · 2021 · 160 citations · Cited by this paper
  36. Innate immune activation in neurodegenerative diseases · Sergio Castro‐Gomez · 2024 · 159 citations · Cited by this paper
  37. Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome · Qing Wei · 2015 · 153 citations · Cited by this paper
  38. Estrogen actions on mitochondria—Physiological and pathological implications · James W. Simpkins · 2008 · 152 citations · Cited by this paper
  39. Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β · Dongqi Xing · 2012 · 151 citations · Cited by this paper

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