Research map: Regulatory endorsement for the application of α-synuclein seed amplification assay as a susceptibility and risk biomarker for clinical trials targeting synucleinopathies

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  1. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease · Mihael H. Polymeropoulos · 1997 · 8352 citations · Cited by this paper
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  26. Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies · Marcello Rossi · 2020 · 486 citations · Cited by this paper
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  28. Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management · João Massano · 2012 · 429 citations · Cited by this paper
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  32. Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein · Ryuichiro Atarashi · 2007 · 351 citations · Cited by this paper
  33. Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study · Álex Iranzo · 2021 · 341 citations · Cited by this paper
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  35. Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking · Ryuichiro Atarashi · 2008 · 317 citations · Cited by this paper
  36. Comparative study of cerebrospinal fluid α‐synuclein seeding aggregation assays for diagnosis of Parkinson's disease · Un Jung Kang · 2019 · 273 citations · Cited by this paper
  37. Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid · Luis Concha‐Marambio · 2023 · 249 citations · Cited by this paper
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