Research map: Local 5% dextrose-based therapies as tissue-level metabolic modulators: a unifying hypothesis for their biological effects

Papers in this map

1. Mechanisms of Insulin Action and Insulin Resistance · Max C. Petersen · 2018 · 3068 citations · Cited by this paper
2. Gut dysbiosis induced mitochondrial epigenetic programming as a determinant of ferroptosis susceptibility · 2026 · Related
3. Wound Healing: A Cellular Perspective · Mélanie Rodrigues · 2018 · 3054 citations · Cited by this paper
4. Neonatal hyperbilirubinemia and potential links to sudden infant death syndrome · 2026 · Related
5. Multi-omics approaches to disease · Yehudit Hasin-Brumshtein · 2017 · 3002 citations · Cited by this paper
6. Synovial fluid for brain disorders: a hypothesis on microenvironmental modulation via cerebrospinal fluid analogy · 2026 · Related
7. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance · Kitt Falk Petersen · 2003 · 2118 citations · Cited by this paper
8. Increased lactate levels in the follicular fluid and plasma of hyperandrogenic PCOS patients might contribute to impaired endometrial receptivity via histone lactylation · 2026 · Related
9. The SLC2 (GLUT) family of membrane transporters · Mike M. Mueckler · 2013 · 1354 citations · Cited by this paper
10. Persistent small intestinal microbial colonisation: a potentially pathological rather than physiological state · 2026 · Related
11. The use of animal models in diabetes research · Aileen King · 2012 · 1311 citations · Cited by this paper
12. The missing biology of synchronization: a mitochondrial hypothesis · 2026 · Related
13. Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation · Felipe Almeida Pinho-Ribeiro · 2016 · 1051 citations · Cited by this paper
14. Failure to downregulate erythropoietin receptor before bone marrow niche exit induces differentiation arrest in non-erythroid hematopoietic progenitors: Implications for leukemia diagnosis and management · 2026 · Related
15. Glycolysis – a key player in the inflammatory response · Gonzalo Soto‐Heredero · 2020 · 683 citations · Cited by this paper
16. Is Cachexia a programmed response to irreversible organ damage? Exploring a CNS-based model · 2026 · Related
17. TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization · Olivier Gouin · 2017 · 445 citations · Cited by this paper
18. Timing as biology: a hypothesis on the role of epigenetic plasticity in type 2 diabetes prevention · 2026 · Related
19. Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation · Stephan Hardivillé · 2014 · 416 citations · Cited by this paper
20. Temporomandibular disorder and Glymphatic insufficiency: The sleep–Proteostasis Axis and locus Coeruleus noradrenergic dysregulation · 2026 · Related
21. Mechanism of increased risk of insulin resistance in aging skeletal muscle · Jian Shou · 2020 · 285 citations · Cited by this paper
22. AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels · David Grahame Hardie · 2014 · 271 citations · Cited by this paper
23. A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain · Ross A. Hauser · 2016 · 247 citations · Cited by this paper
24. Ultrasound-Guided Nerve Hydrodissection for Pain Management: Rationale, Methods, Current Literature, and Theoretical Mechanisms · King Hei Stanley Lam · 2020 · 197 citations · Cited by this paper
25. Three Decades of Research on O-GlcNAcylation – A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism · Gerald Warren Hart · 2014 · 124 citations · Cited by this paper
26. Ultrasound-Guided Nerve Hydrodissection · Shane P. Cass · 2016 · 114 citations · Cited by this paper
27. Glucose transporters in rat peripheral nerve: Paranodal expression of GLUT1 and GLUT3 · Paolo Magnani · 1996 · 74 citations · Cited by this paper
28. Efficacy of 5% Dextrose Water Injection for Peripheral Entrapment Neuropathy: A Narrative Review · Yung‐Tsan Wu · 2021 · 73 citations · Cited by this paper
29. O‐Glc NA cylation: a bridge between glucose and cell differentiation · Chao Sun · 2016 · 47 citations · Cited by this paper
30. Mechanism of Glucose Water as a Neural Injection: A Perspective on Neuroinflammation · Yung‐Tsan Wu · 2022 · 43 citations · Cited by this paper
31. Dextrose injections for failed back surgery syndrome: a consecutive case series · İlker Solmaz · 2019 · 26 citations · Cited by this paper
32. Metabolic Transporters in the Peripheral Nerve—What, Where, and Why? · Atul Kumar Rawat · 2021 · 25 citations · Cited by this paper
33. Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting · Bo‐Syong Pan · 2025 · 21 citations · Cited by this paper
34. Comparison of the Short-Term Clinical Effectiveness of 5% Dextrose Water, Platelet-rich Plasma and Corticosteroid Injections for Carpal Tunnel Syndrome: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials · Nan Gao · 2022 · 20 citations · Cited by this paper
35. Ultrasound-Guided Nerve Hydrodissection for the Management of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis · K.Y. Lee · 2024 · 19 citations · Cited by this paper
36. The role of glucose metabolism in wound healing: an overview · Tao Zhang · 2025 · 18 citations · Cited by this paper
37. Modified prolotherapy by 5% dextrose: Two years experiences of a traditional and complementary medicine practice center in Turkey · İlker Solmaz · 2021 · 11 citations · Cited by this paper
38. Hypertonic dextrose prolotherapy in osteoarthritis: mechanisms, efficacy, and future research directions · Kai Huang · 2025 · 8 citations · Cited by this paper
39. The effect of dextrose prolotherapy on patients diagnosed with knee osteoarthritis: A comprehensive systematic review and meta‐analysis of interventional studies · Sorour Khateri · 2024 · 7 citations · Cited by this paper

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