Research map: Biology, detection, and management of incidental pulmonary nodules: the emerging role of targeted treatments. A review of the current literature and future perspectives

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  1. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening · The National Lung Screening Trial Research Team · 2011 · 11268 citations · Cited by this paper
  2. Epiproteomic profiling identifies histone H4 hyperacetylation as a prognostic marker in pleural mesothelioma · 2026 · Related
  3. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma · William David Travis · 2011 · 4885 citations · Cited by this paper
  4. Neoadjuvant and perioperative chemo-immunotherapy in early-stage non-small cell lung cancer: international expert panel meeting by AIOT · 2026 · Related
  5. The 2015 World Health Organization Classification of Lung Tumors · William David Travis · 2015 · 4653 citations · Cited by this paper
  6. Expert consensus on the evaluation and management of high-risk indeterminate pulmonary nodules · 2024 · Related
  7. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 · Heber MacMahon · 2017 · 2519 citations · Cited by this paper
  8. BRAF fusions define therapeutic vulnerability and tyrosine kinase inhibitor resistance in non-small cell lung cancer · 2026 · Related
  9. The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015 · Andrew Gordon Nicholson · 2021 · 1588 citations · Cited by this paper
  10. Real-world burden of cardiovascular events following immune checkpoint inhibitor therapy: impact on mortality and treatment resumption in 29,503 patients · 2026 · Related
  11. Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? · Michael K. Gould · 2013 · 1474 citations · Cited by this paper
  12. Efficacy and safety of immune checkpoint inhibitors in lung cancer patients with hepatitis B surface antigen positivity: a real-world cohort study · 2026 · Related
  13. EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis · Justin F. Gainor · 2016 · 1271 citations · Cited by this paper
  14. Time-dependent bias in local consolidative therapy for EGFR-mutant metastatic non-small cell lung cancer · 2026 · Related
  15. British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE · Matthew E.J. Callister · 2015 · 963 citations · Cited by this paper
  16. Clonal divergence with acquired BRAF V600E in NSCLC with compound EGFR G719X/S768I after prolonged EGFR-TKI therapy · 2026 · Related
  17. Liquid biopsy: current technology and clinical applications · Mina Nikanjam · 2022 · 938 citations · Cited by this paper
  18. CT surveillance, patterns of recurrence and eligibility for salvage therapy after curative intent treatment for unresectable stage III non small cell lung cancer · 2026 · Related
  19. Recent Trends in the Identification of Incidental Pulmonary Nodules · Michael K. Gould · 2015 · 768 citations · Cited by this paper
  20. First-line treatment for unresectable pulmonary lymphoepithelial carcinoma: A real-world comparison of platinum-based doublet chemotherapy with or without PD-1 inhibitors · 2026 · Related
  21. Evaluating the Patient With a Pulmonary Nodule · Peter J. Mazzone · 2022 · 504 citations · Cited by this paper
  22. Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning · Shuo Wang · 2019 · 446 citations · Cited by this paper
  23. Fleischner Society: Glossary of Terms for Thoracic Imaging · Alexander A. Bankier · 2024 · 413 citations · Cited by this paper
  24. Oncogenic driver mutations in non-small cell lung cancer: Past, present and future · Mathieu Chevallier · 2021 · 324 citations · Cited by this paper
  25. Sybil: A Validated Deep Learning Model to Predict Future Lung Cancer Risk From a Single Low-Dose Chest Computed Tomography · Peter G. Mikhael · 2023 · 284 citations · Cited by this paper
  26. Management of Pulmonary Nodules by Community Pulmonologists · Nichole T. Tanner · 2015 · 182 citations · Cited by this paper
  27. Immune Escape Mechanisms in Non Small Cell Lung Cancer · Andrea Anichini · 2020 · 173 citations · Cited by this paper
  28. EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas · Zhi-Yong Chen · 2012 · 167 citations · Cited by this paper
  29. Mining whole-lung information by artificial intelligence for predicting EGFR genotype and targeted therapy response in lung cancer: a multicohort study · Shuo Wang · 2022 · 163 citations · Cited by this paper
  30. ACR Lung-RADS v2022: Assessment Categories and Management Recommendations · Jared D. Christensen · 2023 · 162 citations · Cited by this paper
  31. Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth · Yoshihisa Kobayashi · 2014 · 148 citations · Cited by this paper
  32. High Discrepancy of Driver Mutations in Patients with NSCLC and Synchronous Multiple Lung Ground-Glass Nodules · Chunyan Wu · 2015 · 147 citations · Cited by this paper
  33. Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up · Alona Zer · 2025 · 135 citations · Cited by this paper
  34. Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I-IIIA Completely Resected Non–Small-Cell Lung Cancer: ASCO Guideline Rapid Recommendation Update · Katherine M.W. Pisters · 2022 · 99 citations · Cited by this paper
  35. Radiomics analysis to predict pulmonary nodule malignancy using machine learning approaches · Matthew T. Warkentin · 2024 · 98 citations · Cited by this paper
  36. Multiomics Analysis Reveals Distinct Immunogenomic Features of Lung Cancer with Ground-Glass Opacity · Kezhong Chen · 2021 · 94 citations · Cited by this paper
  37. Models to Estimate the Probability of Malignancy in Patients with Pulmonary Nodules · Humberto Choi · 2018 · 80 citations · Cited by this paper
  38. Incidental Pulmonary Nodules – What Do We Know in 2022 · Gerald Schmid‐Bindert · 2022 · 57 citations · Cited by this paper
  39. The Probability of Lung Cancer in Patients With Incidentally Detected Pulmonary Nodules · Anil Vachani · 2021 · 49 citations · Cited by this paper

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