Research map: Changes in effectiveness and safety in patients with Lennox–Gastaut syndrome transitioning from the fenfluramine randomized controlled trial to open‐label extension study

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  1. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions · Nicola Specchio · 2022 · 975 citations · Cited by this paper
  2. ILAE ‐ YES global webinar series: Integrating clinical and basic science in epilepsy research · 2026 · Related
  3. Expert Opinion on the Management of Lennox–Gastaut Syndrome: Treatment Algorithms and Practical Considerations · Judith Helen Cross · 2017 · 205 citations · Cited by this paper
  4. KCNQ2 neonatal epilepsy: Impact of prompt diagnosis and treatment, and early predictors of outcome severity · 2026 · Related
  5. Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies · Adam Strzelczyk · 2022 · 177 citations · Cited by this paper
  6. Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States · 2026 · Related
  7. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome · Kelly G. Knupp · 2022 · 136 citations · Cited by this paper
  8. Cumulative electroconvulsive therapy sessions and focal epilepsy: A nationwide cohort study in Japan · 2026 · Related
  9. Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies · Adam Strzelczyk · 2021 · 89 citations · Cited by this paper
  10. Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria · 2026 · Related
  11. Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: Literature review · Katy Gallop · 2009 · 65 citations · Cited by this paper
  12. Epilepsia open —April 2026 announcements · 2026 · Related
  13. Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real‐world study · Nicola Specchio · 2020 · 56 citations · Cited by this paper
  14. The Global Epilepsy Needs Study ( GENS ): A mixed‐methods, multi‐country exploration of the unmet psychosocial and everyday needs of people with epilepsy · 2026 · Related
  15. An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies · Parthena Martin · 2021 · 55 citations · Cited by this paper
  16. Computational protein stability analysis of SCN1A missense variants reveals domain‐dependent stability patterns · 2026 · Related
  17. Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study · Kelly G. Knupp · 2022 · 53 citations · Cited by this paper
  18. Artificial intelligence in the assessment of epilepsy‐related genetic mutations: Learned from GABA A receptors and GABA transporter 1 · 2026 · Related
  19. Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches · Stéphane Auvin · 2024 · 43 citations · Cited by this paper
  20. Impact of Antiseizure Medications on Appetite and Weight in Children · Ersida Buraniqi · 2022 · 31 citations · Cited by this paper
  21. Practical considerations for the use of fenfluramine to manage patients with Dravet syndrome or Lennox–Gastaut syndrome in clinical practice · Elaine C. Wirrell · 2024 · 24 citations · Cited by this paper
  22. In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions · Parthena Martin · 2022 · 23 citations · Cited by this paper
  23. In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions · Parthena Martin · 2022 · 22 citations · Cited by this paper
  24. What have we learned from the real-world efficacy of FFA in DS and LGS? A post-marketing study in clinical practice · Adrián Valls Carbó · 2024 · 14 citations · Cited by this paper
  25. Expert-Agreed Practical Recommendations on the Use of Fenfluramine in Developmental and Epileptic Encephalopathies Based on Clinical Experience and Literature Review · Vicente Villanueva · 2025 · 12 citations · Cited by this paper
  26. Drug-drug interaction between anti-seizure medications in Dravet syndrome and Lennox-Gastaut syndrome · Roberta Roberti · 2025 · 11 citations · Cited by this paper
  27. Final analysis from an open-label extension study of fenfluramine for the treatment of seizures in Lennox-Gastaut syndrome: long-term impact on patients and caregivers · Kelly G. Knupp · 2025 · 8 citations · Cited by this paper
  28. Nonseizure symptoms and broader seizure impacts in patients with Dravet syndrome and Lennox–Gastaut syndrome in clinical practice settings: Results from a multinational survey · Drishti Shah · 2025 · 7 citations · Cited by this paper

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