Research map: Protein neddylation as a therapeutic target: challenges and opportunities

Papers in this map

1. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer · Teresa A. Soucy · 2009 · 2048 citations · Cited by this paper
2. Diabetic and ER-stressed pancreatic islet β cells are in need of some JNK removal · Jonathan M. Palozzi · 2026 · Related
3. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression · Michael J. McMahon · 2003 · 1151 citations · Cited by this paper
4. A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated Caspase-1 inhibition · 2026 · Related
5. The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase · Sara B. Cullinan · 2004 · 991 citations · Cited by this paper
6. Sterol biosynthesis, brain development, and disease · 2026 · Related
7. Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells · Keiyo Takubo · 2010 · 887 citations · Cited by this paper
8. S100A11 regulates hepatic cholesterol metabolism and promotes steatohepatitis via non-canonical SREBP2 signaling · 2026 · Related
9. Protein neddylation: beyond cullin–RING ligases · Radoslav Ivanov Enchev · 2014 · 636 citations · Cited by this paper
10. Genomic characterization of therapy-associated polyposis reveals an alkylating mutational signature from prior treatment · 2026 · Related
11. Identification of a set of genes with developmentally down-regulated expression in the mouse brain · Sharad Kumar · 1992 · 558 citations · Cited by this paper
12. TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo · 2026 · Related
13. Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein · Tetsu Kamitani · 1997 · 548 citations · Cited by this paper
14. Winners of Lasker Foundation Video Contest announced · 2026 · Related
15. Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ · James E. Brownell · 2010 · 471 citations · Cited by this paper
16. The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration · 2026 · Related
17. CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation · Leigh Ann Higa · 2006 · 420 citations · Cited by this paper
18. Histone lysine methyltransferases KMT2C and KMT2D join the all-star tumor suppressor team in gastrointestinal cancer · 2026 · Related
19. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation · Hui Yuan Xiong · 2009 · 396 citations · Cited by this paper
20. Arul M. Chinnaiyan, MD, PhD, and Charles L. Sawyers, MD, receive the 2026 Harrington Prize for Innovation in Medicine · 2026 · Related
21. Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα · Margaret A. Read · 2000 · 365 citations · Cited by this paper
22. A novel protein modification pathway related to the ubiquitin system · Dimitris Liakopoulos · 1998 · 362 citations · Cited by this paper
23. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation · Thomas F. Westbrook · 2008 · 309 citations · Cited by this paper
24. E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification · Danny T. C. Huang · 2009 · 283 citations · Cited by this paper
25. Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line · Yichin Liu · 2003 · 262 citations · Cited by this paper
26. The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth · Zhongguang Luo · 2012 · 246 citations · Cited by this paper
27. Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy · Yongchao Zhao · 2014 · 245 citations · Cited by this paper
28. Pevonedistat ( MLN 4924), a First‐in‐Class NEDD 8‐activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study · Ronan T. Swords · 2015 · 239 citations · Cited by this paper
29. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice · Keisuke Tateishi · 2001 · 234 citations · Cited by this paper
30. Protein neddylation and its alterations in human cancers for targeted therapy · Lisha Zhou · 2018 · 230 citations · Cited by this paper
31. The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis · Ping Xie · 2014 · 210 citations · Cited by this paper
32. Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins · Joris Hemelaar · 2003 · 210 citations · Cited by this paper
33. Targeted inhibition of the COP9 signalosome for treatment of cancer · Anita Schlierf · 2016 · 210 citations · Cited by this paper
34. Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML · Ronan T. Swords · 2018 · 205 citations · Cited by this paper
35. Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation · Thimo Kurz · 2008 · 196 citations · Cited by this paper
36. Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma · Jatin J. Shah · 2015 · 194 citations · Cited by this paper
37. Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence · Shoichiro Takeishi · 2013 · 192 citations · Cited by this paper
38. The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance · Fei Han · 2018 · 191 citations · Cited by this paper
39. Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer · Lihui Li · 2014 · 190 citations · Cited by this paper

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