Research map: 6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

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  1. Regulation of Ferroptotic Cancer Cell Death by GPX4 · Wan Seok Yang · 2014 · 7840 citations · Cited by this paper
  2. Differential metabolic reprogramming and organ-specific antioxidant allocation in Oryza sativa and Echinochloa crus-galli under propanil-induced chemical stress · 2026 · Related
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  5. Deposition of Inhaled Particles in the Human Respiratory Tract and Consequences for Regional Targeting in Respiratory Drug Delivery · Joachim Heyder · 2004 · 605 citations · Cited by this paper
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  7. Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI · Diego Martín‐Sánchez · 2016 · 580 citations · Cited by this paper
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  9. New Evidence of Rubber-Derived Quinones in Water, Air, and Soil · Guodong Cao · 2022 · 537 citations · Cited by this paper
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  11. Regulated necrosis in kidney ischemia-reperfusion injury · Aspasia Pefanis · 2019 · 367 citations · Cited by this paper
  12. Spatially resolved hepatic lipid metabolism perturbation and gut microbiota dysbiosis induced by a novel PFOA alternative in zebrafish (Danio rerio) · 2026 · Related
  13. Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury · Feiyan Lin · 2022 · 216 citations · Cited by this paper
  14. Polystyrene microplastics-induced gut–liver axis injury in mice: Protective effect and mechanisms of sodium humate · 2026 · Related
  15. Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity · Xin Jun Hua · 2023 · 205 citations · Cited by this paper
  16. Integrated analyses of hepatopancreatic response induced by high temperature and its alleviation by astaxanthin in Sinosolenaia oleivora · 2026 · Related
  17. Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers · Eikan Mishima · 2019 · 188 citations · Cited by this paper
  18. Diethylene glycol dibenzoate an emerging plasticizer disrupts bone formation via MMP3 targeting: Insights from bioinformatics and in vitro validation · 2026 · Related
  19. Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis · Bin Huang · 2025 · 170 citations · Cited by this paper
  20. Polystyrene nanoplastics impair placental function and promote embryo resorption through ROS-mediated ferroptosis-related injury · 2026 · Related
  21. Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis · Qian-Jin Zhang · 2021 · 167 citations · Cited by this paper
  22. Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone · Yang Jiang · 2024 · 139 citations · Cited by this paper
  23. Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects · Xiandeng Li · 2023 · 126 citations · Cited by this paper
  24. Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney · Wenyue Qiu · 2023 · 107 citations · Cited by this paper
  25. Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans · Xin Jun Hua · 2023 · 101 citations · Cited by this paper
  26. The Role of the Exocyst in Matrix Metalloproteinase Secretion and Actin Dynamics during Tumor Cell Invadopodia Formation · Jianglan Liu · 2009 · 99 citations · Cited by this paper
  27. The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma · Zhangjie Wang · 2023 · 97 citations · Cited by this paper
  28. Ferroptosis and kidney disease · Diego Martín‐Sánchez · 2020 · 96 citations · Cited by this paper
  29. Plasma membrane phospholipid signature recruits the plant exocyst complex via the EXO70A1 subunit · Lukáš Synek · 2021 · 89 citations · Cited by this paper
  30. MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins · Sandra Stefanovic-Barrett · 2018 · 86 citations · Cited by this paper
  31. Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis · Yue‐Yue Guo · 2024 · 79 citations · Cited by this paper
  32. The role and mechanism of the cGAS–STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure · Zhimin Zhang · 2025 · 78 citations · Cited by this paper
  33. Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans · Zhengying Liu · 2024 · 73 citations · Cited by this paper
  34. SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway · Wen‐Yuan Wu · 2022 · 67 citations · Cited by this paper
  35. Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice · Bo Li · 2025 · 63 citations · Cited by this paper
  36. Research progress on multiple cell death pathways of podocytes in diabetic kidney disease · Can Yang · 2023 · 60 citations · Cited by this paper
  37. ULK1 phosphorylates Exo70 to suppress breast cancer metastasis · Liyuan Mao · 2020 · 59 citations · Cited by this paper
  38. The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis · Haiyun Wang · 2021 · 55 citations · Cited by this paper
  39. Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress · Dan Xia · 2017 · 44 citations · Cited by this paper

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