Research map: Reactive oxygen species (ROS) in cancer: from redox signaling and metabolic plasticity to therapeutic vulnerabilities

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Papers in this map

  1. How mitochondria produce reactive oxygen species · Michael P. Murphy · 2008 · 8271 citations · Cited by this paper
  2. Emerging roles of haemostatic proteins as markers of disease progression and prognosis in breast cancer · 2026 · Related
  3. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease · Brent R. Stockwell · 2017 · 7879 citations · Cited by this paper
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  6. Racial disparities in hepatocellular carcinoma: a TCGA-based gene expression study of Caucasian and Asian populations · 2025 · Related
  7. The DNA-damage response in human biology and disease · Stephen P. Jackson · 2009 · 6215 citations · Cited by this paper
  8. Metabolic plasticity drives specific mechanisms of chemotherapy and targeted therapy resistance in metastatic colorectal cancer · 2025 · Related
  9. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? · Dunyaporn Trachootham · 2009 · 5459 citations · Cited by this paper
  10. Benign, persistent, and invasive: mechanistic and translational approaches to middle‑ear cholesteatoma · 2026 · Related
  11. Oxidative stress, inflammation, and cancer: How are they linked? · Simone Reuter · 2010 · 5437 citations · Cited by this paper
  12. Lorlatinib in advanced ALK-positive NSCLC after prior progression on ALK inhibitors: real-world experience in Russia · 2026 · Related
  13. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling · Paul D. Ray · 2012 · 4431 citations · Cited by this paper
  14. Liquid biopsy in breast cancer: current biomarker platforms and clinical applications · 2026 · Related
  15. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis · Kirill Bersuker · 2019 · 3782 citations · Cited by this paper
  16. More than alternative estrogen receptors: the emerging role of GPER-1 and ERα36 in breast cancer · 2026 · Related
  17. Modulation of oxidative stress as an anticancer strategy · Chiara Gorrini · 2013 · 3626 citations · Cited by this paper
  18. CHD4 and NOX4 expression in thyroid tumor tissues · 2026 · Related
  19. Reactive oxygen species in cancer · Geou‐Yarh Liou · 2010 · 3449 citations · Cited by this paper
  20. Next-generation cancer vaccines: targeting cryptic and non-canonical antigens for precision immunotherapy · 2025 · Related
  21. Immunogenic cell death in cancer and infectious disease · Lorenzo Galluzzi · 2016 · 3157 citations · Cited by this paper
  22. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications · Brent R. Stockwell · 2022 · 3144 citations · Cited by this paper
  23. The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies · Celia Andrés · 2021 · 2776 citations · Cited by this paper
  24. Oxidative Stress in Cancer · John David Hayes · 2020 · 2655 citations · Cited by this paper
  25. Physiological Roles of Mitochondrial Reactive Oxygen Species · Laura A. Sena · 2012 · 2636 citations · Cited by this paper
  26. Association of reactive oxygen species levels and radioresistance in cancer stem cells · Maximilian Diehn · 2009 · 2569 citations · Cited by this paper
  27. Reactive Oxygen Species (ROS)-Based Nanomedicine · Bowen Yang · 2019 · 2476 citations · Cited by this paper
  28. Autophagy promotes ferroptosis by degradation of ferritin · Wen‐Chi Hou · 2016 · 2340 citations · Cited by this paper
  29. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis · Gina M. DeNicola · 2011 · 2307 citations · Cited by this paper
  30. ROS in cancer therapy: the bright side of the moon · Bruno Perillo · 2020 · 2212 citations · Cited by this paper
  31. Causes and consequences of replication stress · Michelle K. Zeman · 2013 · 2177 citations · Cited by this paper
  32. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer · Chao Mao · 2021 · 1936 citations · Cited by this paper
  33. Pre-metastatic niches: organ-specific homes for metastases · Héctor Peinado · 2017 · 1935 citations · Cited by this paper
  34. NRF2, a Transcription Factor for Stress Response and Beyond · Feng He · 2020 · 1809 citations · Cited by this paper
  35. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? · Simran Singh Sabharwal · 2014 · 1656 citations · Cited by this paper
  36. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo · Michael P. Murphy · 2022 · 1451 citations · Cited by this paper
  37. Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements · Vaishali Aggarwal · 2019 · 1236 citations · Cited by this paper
  38. ROS homeostasis and metabolism: a dangerous liason in cancer cells · Emiliano Panieri · 2016 · 1177 citations · Cited by this paper
  39. Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination · Jason Yu · 2016 · 1175 citations · Cited by this paper

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