Research map: HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma

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  1. An integrated encyclopedia of DNA elements in the human genome · Ian Dunham · 2012 · 19875 citations · Cited by this paper
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  17. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia · Johannes A. Zuber · 2011 · 1899 citations · Cited by this paper
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  21. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia · Mark A. Dawson · 2011 · 1542 citations · Cited by this paper
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  23. TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues · Áron Bartha · 2021 · 1119 citations · Cited by this paper
  24. Plasticity in binding confers selectivity in ligand-induced protein degradation · Radosław P. Nowak · 2018 · 646 citations · Cited by this paper
  25. BET inhibitor resistance emerges from leukaemia stem cells · Chun Yew Fong · 2015 · 556 citations · Cited by this paper
  26. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition · Philipp Rathert · 2015 · 526 citations · Cited by this paper
  27. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation · Omer Gilan · 2020 · 446 citations · Cited by this paper
  28. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer · Emily J. Faivre · 2020 · 415 citations · Cited by this paper
  29. Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors · Jaclyn Andricovich · 2018 · 334 citations · Cited by this paper
  30. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression · Tikvah K. Hayes · 2015 · 283 citations · Cited by this paper
  31. Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3 · Ethan V. Abel · 2013 · 246 citations · Cited by this paper
  32. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma · Tim D.D. Somerville · 2018 · 240 citations · Cited by this paper
  33. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma · Elisa M. Noll · 2016 · 234 citations · Cited by this paper
  34. CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer · Mark L. McCleland · 2016 · 232 citations · Cited by this paper
  35. MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies · GuemHee Baek · 2014 · 228 citations · Cited by this paper
  36. Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy · Zhiqiang Wang · 2023 · 213 citations · Cited by this paper
  37. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism · Angelina V. Vaseva · 2018 · 196 citations · Cited by this paper
  38. Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon? · Elisabeth Heßmann · 2016 · 145 citations · Cited by this paper
  39. The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models · Patrick L. Garcia · 2015 · 135 citations · Cited by this paper

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