Research map: Targeting GastrointestinaI Function Beyond GLP-1 to control Appetite

Papers in this map

1. The migrating motor complex: control mechanisms and its role in health and disease · Eveline Deloose · 2012 · 359 citations · Cited by this paper
2. Gut microbiota in obesity: Mechanisms, dietary influences, and therapeutic perspectives · 2026 · Related
3. Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying · Sara Janssen · 2011 · 322 citations · Cited by this paper
4. Persistent symptoms and enteropathy in coeliac disease: clinical considerations and therapeutic opportunities · 2025 · Related
5. Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man · Jan F. Tack · 2000 · 220 citations · Cited by this paper
6. Nutritional management in functional dyspepsia and gastroparesis · 2025 · Related
7. Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction? · George P. Karamanolis · 2006 · 161 citations · Cited by this paper
8. Pancreatic squamous and adenosquamous cell carcinomas: Rare histologies causing clinical challenges · 2026 · Related
9. The influence of cisapride on gastric tone and the perception of gastric distension · Jan F. Tack · 1998 · 155 citations · Cited by this paper
10. A comprehensive guide to intestinal ultrasound in ulcerative colitis · 2025 · Related
11. Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways · Ki‐Suk Kim · 2014 · 139 citations · Cited by this paper
12. Role of non-exposed endoscopic full thickness resection in the gastrointestinal tract · 2026 · Related
13. Food and Symptom Generation in Functional Gastrointestinal Disorders: Physiological Aspects · Ricard Farré · 2013 · 132 citations · Cited by this paper
14. Advanced diagnostic and resection endoscopic techniques in managing colitis-associated neoplasia: standard of care or still utopia? · 2025 · Related
15. Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide · Ryan J. Jalleh · 2024 · 131 citations · Cited by this paper
16. Training in endoscopic submucosal dissection: Current models and future needs · 2026 · Related
17. Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia—a multicenter, double‐blind, randomized, placebo‐controlled study · Hidekazu Suzuki · 2014 · 129 citations · Cited by this paper
18. Systemic treatment of advanced biliary tract cancers: moving from ‘all-comers’ to precision medicine · 2026 · Related
19. Gastric Sensorimotor Functions and Hormone Profile in Normal Weight, Overweight, and Obese People · Maria I. Vazquez Roque · 2006 · 111 citations · Cited by this paper
20. Colorectal ESD from basics to latest innovations! · 2026 · Related
21. Mechanisms of activation of mouse and human enteroendocrine cells by nutrients · Erin Leigh Symonds · 2014 · 111 citations · Cited by this paper
22. Motilin-induced gastric contractions signal hunger in man · Jan F. Tack · 2014 · 102 citations · Cited by this paper
23. The gastrointestinal tract in hunger and satiety signalling · Jan F. Tack · 2021 · 102 citations · Cited by this paper
24. Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation · Pieter Janssen · 2011 · 97 citations · Cited by this paper
25. The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice · Tomoaki Matsumura · 2009 · 95 citations · Cited by this paper
26. Influence of buspirone on gastric sensorimotor function in man · Lukas Van Oudenhove · 2008 · 92 citations · Cited by this paper
27. Effect of a novel 5‐HT3 receptor agonist MKC‐733 on upper gastrointestinal motility in humans · Nicholas S. Coleman · 2003 · 87 citations · Cited by this paper
28. Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture · Deborah A. Goldspink · 2020 · 87 citations · Cited by this paper
29. Treatment of morbid obesity by intraparietogastric administration of botulinum toxin: a randomized, double-blind, controlled study · Diego Foschi · 2006 · 85 citations · Cited by this paper
30. Motilin: from gastric motility stimulation to hunger signalling · Eveline Deloose · 2019 · 83 citations · Cited by this paper
31. Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers · Eveline Deloose · 2017 · 73 citations · Cited by this paper
32. Rikkunshito, a ghrelin potentiator, ameliorates anorexia–cachexia syndrome · Naoki Fujitsuka · 2014 · 72 citations · Cited by this paper
33. Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study · Daniele Gui · 2006 · 69 citations · Cited by this paper
34. The Function of Gastrointestinal Hormones in Obesity—Implications for the Regulation of Energy Intake · Mona Farhadipour · 2021 · 58 citations · Cited by this paper
35. 5-Hydroxytryptamine-3 receptors are involved in the initiation of gastric phase-3 motor activity in humans · Alexander Wilmer · 1993 · 57 citations · Cited by this paper
36. Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut · Qiaoling Wang · 2019 · 52 citations · Cited by this paper
37. Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers · Eveline Deloose · 2017 · 51 citations · Cited by this paper
38. Gastric Antral Injections of Botulinum Toxin Delay Gastric Emptying but Do Not Reduce Body Weight · Mark D. Topazian · 2012 · 46 citations · Cited by this paper
39. Intragastric quinine administration decreases hedonic eating in healthy women through peptide-mediated gut-brain signaling mechanisms · Julie Iven · 2018 · 46 citations · Cited by this paper

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