Research map: Pulse-resolved tumor control probability modeling for FLASH radiotherapy using a variable-time treatment-course framework

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  1. The hazard of accelerated tumor clonogen repopulation during radiotherapy · H. Rodney Withers · 1988 · 1607 citations · Cited by this paper
  2. UNetrDose: a fast and accurate transformer-based dose prediction model for radiotherapy · 2026 · Related
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  11. The mechanism of the induction by radiation of chromosome aberrations inTradescantia · D. E. Lea · 1942 · 418 citations · Cited by this paper
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  13. How low is the α/β ratio for prostate cancer? · Jian Z. Wang · 2002 · 335 citations · Cited by this paper
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  15. A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect · Rudi Labarbe · 2020 · 207 citations · Cited by this paper
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  17. Tumour control probability: a formulation applicable to any temporal protocol of dose delivery · Marco Zaider · 1999 · 177 citations · Cited by this paper
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  19. A computational model of radiolytic oxygen depletion during FLASH irradiation and its effect on the oxygen enhancement ratio · Guillem Pratx · 2019 · 170 citations · Cited by this paper
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  21. A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy · Kristoffer Petersson · 2020 · 149 citations · Cited by this paper
  22. Biological Factors Influencing Optimum Fractionation in Radiation Therapy · Jack F. Fowler · 2001 · 134 citations · Cited by this paper
  23. Initial Slope of Radiation Survival Curves Is Characteristic of the Origin of Primary and Established Cultures of Human Tumor Cells and Fibroblasts · E.P. Malaise · 1987 · 118 citations · Cited by this paper
  24. FLASH radiotherapy with carbon ion beams · Uli Andreas Weber · 2021 · 114 citations · Cited by this paper
  25. A Generalized Formulation of the ‘Incomplete-repair’ Model for Cell Survival and Tissue Response to Fractionated Low Dose-rate Irradiation · Per Gunnar Nilsson · 1990 · 95 citations · Cited by this paper
  26. Analysis of a large number of clinical studies for breast cancer radiotherapy: estimation of radiobiological parameters for treatment planning · Mariana Guerrero · 2003 · 50 citations · Cited by this paper
  27. A Theory of the Action of Radiations on Biological Materials Capable of Recovery Part 1 · D. E. Lea · 1938 · 47 citations · Cited by this paper
  28. Treatment planning considerations for the development of FLASH proton therapy · Bethany Rothwell · 2022 · 47 citations · Cited by this paper
  29. Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water · Jeannette Jansen · 2022 · 42 citations · Cited by this paper
  30. Current views on mechanisms of the FLASH effect in cancer radiotherapy · Yuqi Ma · 2024 · 41 citations · Cited by this paper
  31. Deciphering Time-Dependent DNA Damage Complexity, Repair, and Oxygen Tension: A Mechanistic Model for FLASH-Dose-Rate Radiation Therapy · Hans Liew · 2021 · 37 citations · Cited by this paper
  32. Modeling of cellular response after FLASH irradiation: a quantitative analysis based on the radiolytic oxygen depletion hypothesis · Hongyu Zhu · 2021 · 34 citations · Cited by this paper
  33. Intertrack interaction at ultra-high dose rates and its role in the FLASH effect · Alexander Baikalov · 2023 · 22 citations · Cited by this paper
  34. A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply · Wei Zou · 2022 · 20 citations · Cited by this paper
  35. Will intrafraction repair have negative consequences on extreme hypofractionation in prostate radiation therapy? · Alexandru Daşu · 2015 · 13 citations · Cited by this paper
  36. The Impact of Sub-Millisecond Damage Fixation Kinetics on the In Vitro Sparing Effect at Ultra-High Dose Rate in UNIVERSE · Hans Liew · 2022 · 12 citations · Cited by this paper
  37. Do We Preserve Tumor Control Probability (TCP) in FLASH Radiotherapy? A Model-Based Analysis · Hans Liew · 2023 · 7 citations · Cited by this paper
  38. Development of generalized time-dependent TCP model and the investigation of the effect of repopulation and weekend breaks in fractionated external beam therapy · Tae Kyu Lee · 2020 · 5 citations · Cited by this paper
  39. An in-silico study of conventional and FLASH radiotherapy iso-effectiveness: potential impact of radiolytic oxygen depletion on tumor growth curves and tumor control probability · Isabel González‐Crespo · 2024 · 4 citations · Cited by this paper

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