Research map: Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

Back to the article

Papers in this map

  1. Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer · Herbert I. Hurwitz · 2004 · 11034 citations · Cited by this paper
  2. Reliability of Ultrasonography to Assess Spinal Compression During Heavy Load Carriage · 2026 · Related
  3. Human mesenchymal stem cells modulate allogeneic immune cell responses · Sudeepta Aggarwal · 2004 · 4568 citations · Cited by this paper
  4. Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines · 2025 · Related
  5. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli · Massimo Di Nicola · 2002 · 3228 citations · Cited by this paper
  6. In‐Field Ecological Momentary Assessment From Wearable Motion Sensors and Self‐Report in a Chronic Low Back Pain Cohort · 2026 · Related
  7. RNA delivery by extracellular vesicles in mammalian cells and its applications · Killian P. O’Brien · 2020 · 1881 citations · Cited by this paper
  8. A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology · 2026 · Related
  9. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 · Manuela Loureiro Ferreira · 2023 · 1738 citations · Cited by this paper
  10. Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration · 2026 · Related
  11. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation · William T. Tse · 2003 · 1507 citations · Cited by this paper
  12. Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet) · 2026 · Related
  13. New In Vivo Measurements of Pressures in the Intervertebral Disc in Daily Life · Hans‐Joachim Wilke · 1999 · 1503 citations · Cited by this paper
  14. What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain · 2025 · Related
  15. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges · Dinh Ha · 2016 · 1373 citations · Cited by this paper
  16. Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult · 2025 · Related
  17. Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex · Katarina Le Blanc · 2003 · 1372 citations · Cited by this paper
  18. Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition · 2025 · Related
  19. A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype · Ruth S. Waterman · 2010 · 1256 citations · Cited by this paper
  20. Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV‐idence ? · 2025 · Related
  21. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine · Matthew B. Murphy · 2013 · 1253 citations · Cited by this paper
  22. Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter · Charles Pin‐Kuang Lai · 2014 · 938 citations · Cited by this paper
  23. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis · Fei Liu · 2014 · 874 citations · Cited by this paper
  24. The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration · Christine Lyn Le Maitre · 2005 · 820 citations · Cited by this paper
  25. Biology of Intervertebral Disc Aging and Degeneration · Peter J. Roughley · 2004 · 792 citations · Cited by this paper
  26. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis · Elena González‐Rey · 2009 · 700 citations · Cited by this paper
  27. Off-target effects in CRISPR/Cas9 gene editing · Congting Guo · 2023 · 615 citations · Cited by this paper
  28. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile · Christine Lyn Le Maitre · 2007 · 593 citations · Cited by this paper
  29. Stem cell therapy for intervertebral disc regeneration: obstacles and solutions · Daisuke Sakai · 2015 · 490 citations · Cited by this paper
  30. Inflammation in intervertebral disc degeneration and regeneration · Maria Molinos · 2015 · 460 citations · Cited by this paper
  31. Disc Degeneration Affects the Multidirectional Flexibility of the Lumbar Spine · Masaya Mimura · 1994 · 428 citations · Cited by this paper
  32. Mesenchymal stromal cell ‘licensing’: a multistep process · Mauro Krampera · 2011 · 363 citations · Cited by this paper
  33. Biomaterials for intervertebral disc regeneration and repair · Robert D. Bowles · 2017 · 348 citations · Cited by this paper
  34. Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation · Kyung‐Suk Choi · 2008 · 318 citations · Cited by this paper
  35. Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements · Johnny van Doorn · 2011 · 306 citations · Cited by this paper
  36. Cell-based strategies for IVD repair: clinical progress and translational obstacles · Abbie L. A. Binch · 2021 · 305 citations · Cited by this paper
  37. Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging · James C. Iatridis · 1997 · 293 citations · Cited by this paper
  38. Intervertebral Disc Cell–Mediated Mesenchymal Stem Cell Differentiation · Stephen M. Richardson · 2005 · 288 citations · Cited by this paper
  39. Osteogenic Protein-1 Injection Into a Degenerated Disc Induces the Restoration of Disc Height and Structural Changes in the Rabbit Anular Puncture Model · Koichi Masuda · 2006 · 288 citations · Cited by this paper

Source: OpenAlex (CC0)