Research map: Therapeutic and research frontiers in fibromyalgia: integrating pathophysiology with innovative drug repurposing

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Papers in this map

  1. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria · Frederick Wolfe · 2016 · 2227 citations · Cited by this paper
  2. REJENERA©, a multi-component bioflavonoid-based formula, alleviates osteoarthritis and provides chondroprotection by regulating the NLRP3-TXNIP-iNOS axis and inflammation: a comparative study with olive leaf nutraceuticals and ibuprofen · 2026 · Related
  3. EULAR revised recommendations for the management of fibromyalgia · Gary John Macfarlane · 2016 · 1560 citations · Cited by this paper
  4. Antioxidative and anti-inflammatory effects of monoterpene linalool in rats with letrozole-induced polycystic ovarian syndrome: modulation of autophagy and apoptosis · 2026 · Related
  5. Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome · Irwin Jon Russell · 1994 · 680 citations · Cited by this paper
  6. Mangiferin in combination with primaquine reduces disease progression and transmission potential while alleviating cerebral pathology through suppression of neural cell apoptosis in experimental cerebral malaria · 2026 · Related
  7. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update · Rosalba Siracusa · 2021 · 663 citations · Cited by this paper
  8. Cucurbitacin derivatives (B, IIa, IIb, and E): modulating gut dysbiosis and inflammatory pathways for multi-target therapy of ulcerative colitis · 2026 · Related
  9. Spinal cord mechanisms of pain · Richard D’Mello · 2008 · 652 citations · Cited by this paper
  10. Regulation of NLRP3 inflammasome signaling in Alzheimer’s disease: emerging neuroprotective role of phytochemicals · 2026 · Related
  11. p38 MAPK, Microglial Signaling, and Neuropathic Pain · Ru‐Rong Ji · 2007 · 627 citations · Cited by this paper
  12. Agomelatine for Sjögren’s syndrome: a study on its therapeutic effects and mechanisms · 2026 · Related
  13. Astrocytes in chronic pain and itch · Ru‐Rong Ji · 2019 · 588 citations · Cited by this paper
  14. Efficacy of Low‐Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12‐Month Randomised, Double‐Blind, Placebo‐Controlled Single‐Centre Clinical Trial ( INNOVA Study) · 2026 · Related
  15. The neuropathic pain: An overview of the current treatment and future therapeutic approaches · Eugenio Cavalli · 2019 · 502 citations · Cited by this paper
  16. Low-dose naltrexone for fibromyalgia: a re-analysis suggests lower efficacy than previously reported · 2025 · Related
  17. Emerging importance of satellite glia in nervous system function and dysfunction · Menachem Hanani · 2020 · 406 citations · Cited by this paper
  18. Possible Interaction of Suramin with Thalamic P2X Receptors and NLRP3 Inflammasome Activation Alleviates Reserpine-Induced Fibromyalgia-Like Symptoms · 2025 · Related
  19. Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study · Robert M. Bennett · 2003 · 405 citations · Cited by this paper
  20. Melatonin Mitigates Central Sensitization and Nociplastic Pain in Spinal Cord and Dorsal Root Ganglia of FM Rat Model: Modulation of SIRT1/PGC-1α/MAPK/NF-κB Signaling · 2026 · Related
  21. Nabilone for the Treatment of Pain in Fibromyalgia · Ryan Q. Skrabek · 2007 · 383 citations · Cited by this paper
  22. Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain · Christopher R. Donnelly · 2020 · 330 citations · Cited by this paper
  23. The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial · Mark A. Ware · 2010 · 313 citations · Cited by this paper
  24. A randomized, double‐blind, placebo‐controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications · Andrew J. Holman · 2005 · 289 citations · Cited by this paper
  25. Passive transfer of fibromyalgia symptoms from patients to mice · Andreas Göebel · 2021 · 285 citations · Cited by this paper
  26. Altered microbiome composition in individuals with fibromyalgia · Amir Minerbi · 2019 · 225 citations · Cited by this paper
  27. The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors · Xiaoyan Zhan · 2023 · 181 citations · Cited by this paper
  28. Microglia polarization in nociplastic pain: mechanisms and perspectives · Ahd A. Atta · 2023 · 176 citations · Cited by this paper
  29. AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome · Pedro Bullón · 2015 · 119 citations · Cited by this paper
  30. Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial · Simone de Azevedo Zanette · 2014 · 118 citations · Cited by this paper
  31. Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial · Carolina Chaves · 2020 · 117 citations · Cited by this paper
  32. Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms · Huan-Jun Lu · 2022 · 116 citations · Cited by this paper
  33. Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia · Luke Parkitny · 2017 · 113 citations · Cited by this paper
  34. Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice · Eduarda Gomes Ferrarini · 2022 · 106 citations · Cited by this paper
  35. Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: Results from a 14-week, randomized, double-blind, placebo-controlled study · Jon I. Russell · 2011 · 102 citations · Cited by this paper
  36. NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q 10 · Mario David Cordero · 2013 · 102 citations · Cited by this paper
  37. Bowel dysfunction and irritable bowel syndrome in fibromyalgia patients · Ayşen Sivri · 1996 · 91 citations · Cited by this paper
  38. Fibromyalgia Pathophysiology · Michael J. Gyorfi · 2022 · 89 citations · Cited by this paper
  39. Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up · Bárbara Oliván‐Blázquez · 2014 · 87 citations · Cited by this paper

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