Research map: Microglial immunometabolic reprogramming in Alzheimer's disease: From mitochondrial dysfunction and redox imbalance to NLRP3 inflammasome-driven neuroinflammation

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  1. Neurotoxic reactive astrocytes are induced by activated microglia · Shane A. Liddelow · 2017 · 8394 citations · Cited by this paper
  2. Does HIV-1 infection drive Alzheimer’s disease pathobiology? · Elizabeth Etafo · 2026 · Cites this paper
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  8. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? · Fangda Leng · 2020 · 3295 citations · Cited by this paper
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  10. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases · Susanne Krasemann · 2017 · 3194 citations · Cited by this paper
  11. Associations between higher-order executive planning and subjective cognitive decline in middle-aged individuals · 2026 · Related
  12. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice · Michael Thomas Heneka · 2012 · 2962 citations · Cited by this paper
  13. Recruitment challenges and strategies for engaging the Peruvian population in the ReDLat Study · 2026 · Related
  14. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup · Clifford R. Jack · 2024 · 2682 citations · Cited by this paper
  15. Disease burden of Alzheimer's disease and other dementias in older adults · 2026 · Related
  16. Gut microbiome alterations in Alzheimer’s disease · Nicholas M. Vogt · 2017 · 2174 citations · Cited by this paper
  17. Performance of the participant self-rating version of the Quick Dementia Rating System in a racially diverse cohort of non-demented older adults · 2026 · Related
  18. Blood-Brain Barrier Breakdown in the Aging Human Hippocampus · Axel Montagne · 2015 · 2171 citations · Cited by this paper
  19. Precuneus amyloid-β deposition involving the association of irritability and cognitive decline: A multi-cohort longitudinal study · 2026 · Related
  20. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 · Evanna L. Mills · 2018 · 1944 citations · Cited by this paper
  21. Protocol for a Randomized Phase II/III Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Extended-Release Metformin in Amnestic Mild Cognitive Impairment · 2025 · Related
  22. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease · Evandro Fei Fang · 2019 · 1774 citations · Cited by this paper
  23. NLRP3 inflammasome activation drives tau pathology · Christina Ising · 2019 · 1587 citations · Cited by this paper
  24. The glymphatic pathway in neurological disorders · Martin Kaag Rasmussen · 2018 · 1577 citations · Cited by this paper
  25. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease · Tyler Kent Ulland · 2017 · 1326 citations · Cited by this paper
  26. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation · Zhenyu Zhong · 2018 · 1214 citations · Cited by this paper
  27. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease · Carmen Venegas · 2017 · 1018 citations · Cited by this paper
  28. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease · Sung Hoon Baik · 2019 · 890 citations · Cited by this paper
  29. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling · Hongxu Xian · 2022 · 844 citations · Cited by this paper
  30. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge · Alicia A. Nugent · 2020 · 787 citations · Cited by this paper
  31. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease · Raymond Scott Turner · 2015 · 737 citations · Cited by this paper
  32. Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains · Douglas M. Zeppenfeld · 2016 · 664 citations · Cited by this paper
  33. Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease · Afzal Ali Misrani · 2021 · 657 citations · Cited by this paper
  34. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease · Hong Lian · 2016 · 630 citations · Cited by this paper
  35. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation · Alexander Hooftman · 2020 · 623 citations · Cited by this paper
  36. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice · Colin Dempsey · 2016 · 589 citations · Cited by this paper
  37. The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease · Marina Saresella · 2016 · 498 citations · Cited by this paper
  38. NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency · Yujun Hou · 2018 · 486 citations · Cited by this paper
  39. Human microglial state dynamics in Alzheimer’s disease progression · Na Sun · 2023 · 464 citations · Cited by this paper

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