Research map: Quantifying the aromatic amino acid metabolome: UPLC-MS/MS analysis of aromatic amino acids and their host and co-metabolites in plasma

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  1. Amino acids: metabolism, functions, and nutrition · Guoyao Wu · 2009 · 3036 citations · Cited by this paper
  2. A systematic profiling of chemicalome and metabolome of Citrus aurantium ‘Changshan-huyou’ flavonoids to provide insights into its potential in vivo pharmacodynamic material basis · 2026 · Related
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  9. Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain2 · John D. Fernstrom · 2007 · 759 citations · Cited by this paper
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  11. Kynurenine pathway metabolism and the microbiota-gut-brain axis · Paul J. Kennedy · 2016 · 741 citations · Cited by this paper
  12. Characterization of lipophilic oil fraction from Primula vulgaris: Chemical profile, antioxidant capacity, and DNA damage assessment · 2026 · Related
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  14. Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantification of twenty-five steroids in equine serum · 2026 · Related
  15. p-Cresyl Sulfate · Tessa Gryp · 2017 · 421 citations · Cited by this paper
  16. Selective monitoring of trace-level catechin and myricetin in herbal and aqueous matrices using magnetic MIP–DSPME: Optimization via design of experiments · 2026 · Related
  17. Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120 · Wen-Chih Liu · 2018 · 194 citations · Cited by this paper
  18. Enzyme inhibition and antioxidant properties of different Melissa officinalis L. extracts: experimental, DFT, molecular docking and molecular dynamics based analyses · 2026 · Related
  19. Capillary electrophoresis–mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments · Harald Mischak · 2008 · 191 citations · Cited by this paper
  20. Comparative evaluation of native and fluorinated amino acid probes in stereoselective plasma profiling: A proof-of-concept study by chiral LC–MS/MS · 2026 · Related
  21. The Role of Tryptophan Metabolites in Neuropsychiatric Disorders · Majid Davidson · 2022 · 167 citations · Cited by this paper
  22. Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system · Moein Ala · 2021 · 160 citations · Cited by this paper
  23. LC–MS/MS-Based Quantification of Kynurenine Metabolites, Tryptophan, Monoamines and Neopterin in Plasma, Cerebrospinal Fluid and Brain · René Fuertig · 2016 · 159 citations · Cited by this paper
  24. Accumulation of toxic products degradation of kynurenine in hemodialyzed patients · Dariusz Pawlak · 2001 · 104 citations · Cited by this paper
  25. Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota–brain axis · Kan Gao · 2019 · 104 citations · Cited by this paper
  26. Protocol for quality control in metabolic profiling of biological fluids by U(H)PLC-MS · Helen Gika · 2015 · 100 citations · Cited by this paper
  27. A review of validated biomarkers obtained through metabolomics · Ángeles López-López · 2018 · 97 citations · Cited by this paper
  28. Roles of the tyrosine isomers meta- tyrosine and ortho- tyrosine in oxidative stress · Brett R. Ipson · 2016 · 94 citations · Cited by this paper
  29. Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function · Niall P. Hyland · 2022 · 93 citations · Cited by this paper
  30. Development, validation and application of LC–MS/MS method for quantification of amino acids, kynurenine and serotonin in human plasma · Dávid Virág · 2019 · 77 citations · Cited by this paper
  31. Indole metabolites and colorectal cancer: Gut microbial tryptophan metabolism, host gut microbiome biomarkers, and potential intervention mechanisms · Yufei Liu · 2023 · 77 citations · Cited by this paper
  32. Identification of sulfation sites of metabolites and prediction of the compounds’ biological effects · Lin Yi · 2006 · 70 citations · Cited by this paper
  33. A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis · Ferenc Tömösi · 2020 · 68 citations · Cited by this paper
  34. Metabolic Profiling of Human Plasma and Urine, Targeting Tryptophan, Tyrosine and Branched Chain Amino Acid Pathways · Andrea Anesi · 2019 · 66 citations · Cited by this paper
  35. Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects · Stephanie Herman · 2019 · 57 citations · Cited by this paper
  36. Placebo-Controlled Comparison of Three Dose-Regimens of 5-Hydroxytryptophan Challenge Test in Healthy Volunteers · Harm J. Gijsman · 2002 · 55 citations · Cited by this paper
  37. Enantioselective capillary electrophoresis-mass spectrometry of amino acids in cerebrospinal fluid using a chiral derivatizing agent and volatile surfactant · Amir Prior · 2016 · 47 citations · Cited by this paper
  38. Evaluation of volumetric blood collection devices for the measurement of phenylalanine and tyrosine to monitor patients with phenylketonuria · Rachel S. Carling · 2022 · 37 citations · Cited by this paper
  39. Simultaneous measurement of kynurenine metabolites and explorative metabolomics using liquid chromatography-mass spectrometry: A novel accurate method applied to serum and plasma samples from a large healthy cohort · Peter Preben Eggertsen · 2023 · 34 citations · Cited by this paper

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