Research map: Combined treatment with metformin and melatonin improves placental mitochondrial function via the AMPK/SIRT3 pathway in an LPS-induced model of preeclampsia

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  1. Preeclampsia—Pathophysiology and Clinical Presentations · Christopher W. Ives · 2020 · 876 citations · Cited by this paper
  2. Characteristics Three waves of pyripyropene fungal alkaloids and synthetic derivatives targeting ACAT2 as insecticides, anti-atherosclerosis and anticancer agents. · 2026 · Related
  3. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology · Russel Joseph Reiter · 2013 · 383 citations · Cited by this paper
  4. Low-molecular-weight fucoidan inhibits HMGB1-induced thromboinflammation by modulating HMGB1-TLR4 axis · 2026 · Related
  5. The role of immune cells and mediators in preeclampsia · Evangeline M. Deer · 2023 · 293 citations · Cited by this paper
  6. Poly(I:C) and QS-21 combination suppresses breast tumor growth and metastasis by repolarizing tumor associated macrophages to anti-tumor macrophages · 2026 · Related
  7. Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction · Fiona Brownfoot · 2015 · 227 citations · Cited by this paper
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  9. Roll-out of SARS-CoV-2 testing for healthcare workers at a large NHS Foundation Trust in the United Kingdom, March 2020 · Alexander James Keeley · 2020 · 192 citations · Cited by this paper
  10. PGC-1α mediates ER stress–driven apoptotic signaling during gemfibrozil treatment in glioblastoma · 2026 · Related
  11. A Narrative Review on the Pathophysiology of Preeclampsia · Johnatan Torres‐Torres · 2024 · 177 citations · Cited by this paper
  12. CTSB-Associated Inflammation and Macrophage Interaction in Heart Failure Following Myocardial Infarction and Potential Therapeutic Implications of Quercetin · 2026 · Related
  13. Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early‐onset preeclampsia · Sebastian Rupert Hobson · 2018 · 149 citations · Cited by this paper
  14. S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis · 2026 · Related
  15. Risk of pre‐eclampsia in women taking metformin: a systematic review and meta‐analysis · Abdelrahim M. Alqudah · 2017 · 122 citations · Cited by this paper
  16. Induction and Propagation of Ferroptosis Evasion by FTH1P7 Drives Sorafenib Resistance in Hepatocellular Carcinoma · 2026 · Related
  17. Prevalence of preeclampsia and eclampsia in adolescent pregnancy: A systematic review and meta-analysis of 291,247 adolescents worldwide since 1969 · Tereza Callou Couto Macedo · 2020 · 119 citations · Cited by this paper
  18. A functional coupling of TRPA1 and TMEM16A channels regulates endothelium-dependent hyperpolarization-mediated vasorelaxation of mesenteric resistance arteries in healthy and septic mice · 2026 · Related
  19. Melatonin: the placental antioxidant and anti-inflammatory · Tyana T. Joseph · 2024 · 112 citations · Cited by this paper
  20. Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion‐induced oxidative/nitrosative mitochondrial damage in the placenta · Ryuhei Nagai · 2008 · 89 citations · Cited by this paper
  21. Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia · Padma Murthi · 2020 · 69 citations · Cited by this paper
  22. Placental Mitochondrial Function and Dysfunction in Preeclampsia · Fahmida Jahan · 2023 · 68 citations · Cited by this paper
  23. Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation · Lin Han · 2020 · 52 citations · Cited by this paper
  24. Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis · Taylor Gillmore · 2022 · 30 citations · Cited by this paper
  25. Protective role of metformin in preeclampsia via the regulation of NF-κB/sFlt-1 and Nrf2/HO-1 signaling pathways by activating AMPK · Lidan He · 2023 · 29 citations · Cited by this paper
  26. The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation · Mohanlall Narine · 2023 · 28 citations · Cited by this paper
  27. Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model · Peng Ping Xie · 2021 · 26 citations · Cited by this paper
  28. The Role of Placental Mitochondrial Dysfunction in Adverse Perinatal Outcomes: A Systematic Review · Charalampos Voros · 2025 · 26 citations · Cited by this paper
  29. Is Mitochondrial Oxidative Stress a Viable Therapeutic Target in Preeclampsia? · Venkata Ramana Vaka · 2022 · 25 citations · Cited by this paper
  30. Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae · Yunhui Tang · 2021 · 23 citations · Cited by this paper
  31. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis · Caren M. van Kammen · 2024 · 21 citations · Cited by this paper
  32. Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome · Russel Joseph Reiter · 2024 · 20 citations · Cited by this paper
  33. Current Studies of Mitochondrial Quality Control in the Preeclampsia · Xiaoqing Peng · 2022 · 19 citations · Cited by this paper
  34. Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia · Zi Lv · 2022 · 19 citations · Cited by this paper
  35. The Role of Mitochondrial Dysfunction and Oxidative Stress in Women’s Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia · Evangeline M. Deer · 2025 · 16 citations · Cited by this paper
  36. A comparison of rat models that best mimic immune-driven preeclampsia in humans · Fahmida Jahan · 2023 · 15 citations · Cited by this paper
  37. Metformin inhibits activation of NLRP3 inflammasome and inflammatory response in preeclamptic rats · Ran Jia · 2024 · 11 citations · Cited by this paper
  38. SIRT3 impairment and MnSOD hyperacetylation in trophoblast dysfunction and preeclampsia · Yang-Nan Ding · 2025 · 11 citations · Cited by this paper
  39. The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression · Sapna Ramdin · 2023 · 10 citations · Cited by this paper

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