Research map: Pulmonary fibrosis and the TGF-β signaling axis: Advances in targeted therapeutics

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Papers in this map

  1. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis · Talmadge E. King · 2014 · 4057 citations · Cited by this paper
  2. Characteristics Three waves of pyripyropene fungal alkaloids and synthetic derivatives targeting ACAT2 as insecticides, anti-atherosclerosis and anticancer agents. · 2026 · Related
  3. TGF-β: the master regulator of fibrosis · Xiao‐Ming Meng · 2016 · 3605 citations · Cited by this paper
  4. Low-molecular-weight fucoidan inhibits HMGB1-induced thromboinflammation by modulating HMGB1-TLR4 axis · 2026 · Related
  5. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline · Ganesh Raghu · 2022 · 2852 citations · Cited by this paper
  6. Poly(I:C) and QS-21 combination suppresses breast tumor growth and metastasis by repolarizing tumor associated macrophages to anti-tumor macrophages · 2026 · Related
  7. SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS · Xin‐Hua Feng · 2005 · 1884 citations · Cited by this paper
  8. Rebastinib inhibits cerebral cavernous malformation in a chronic mouse model · 2026 · Related
  9. Non-Smad pathways in TGF-β signaling · Ying E. Zhang · 2008 · 1744 citations · Cited by this paper
  10. PGC-1α mediates ER stress–driven apoptotic signaling during gemfibrozil treatment in glioblastoma · 2026 · Related
  11. Mechanisms and functions of p38 MAPK signalling · Ana Cuadrado · 2010 · 1692 citations · Cited by this paper
  12. CTSB-Associated Inflammation and Macrophage Interaction in Heart Failure Following Myocardial Infarction and Potential Therapeutic Implications of Quercetin · 2026 · Related
  13. Targeting PI3K in cancer: mechanisms and advances in clinical trials · Jing Yang · 2019 · 1579 citations · Cited by this paper
  14. S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis · 2026 · Related
  15. Wnt signal transduction pathways · Yuko Komiya · 2008 · 1552 citations · Cited by this paper
  16. Induction and Propagation of Ferroptosis Evasion by FTH1P7 Drives Sorafenib Resistance in Hepatocellular Carcinoma · 2026 · Related
  17. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis · Taylor Sterling Adams · 2020 · 1501 citations · Cited by this paper
  18. A functional coupling of TRPA1 and TMEM16A channels regulates endothelium-dependent hyperpolarization-mediated vasorelaxation of mesenteric resistance arteries in healthy and septic mice · 2026 · Related
  19. TGF-β signaling in fibrosis · Anna Biernacka · 2011 · 1190 citations · Cited by this paper
  20. HIPK2 attenuates bleomycin-induced pulmonary fibrosis by suppressing the Wnt/β-catenin signaling pathway · 2022 · Related
  21. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover · Gianni M. Di Guglielmo · 2003 · 1180 citations · Cited by this paper
  22. The JNK signal transduction pathway · Claire R. Weston · 2007 · 1038 citations · Cited by this paper
  23. Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review · John Hutchinson · 2015 · 957 citations · Cited by this paper
  24. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β · José G. Abreu · 2002 · 906 citations · Cited by this paper
  25. Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity · Barish Ozdamar · 2005 · 885 citations · Cited by this paper
  26. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis · Christina Morse · 2019 · 885 citations · Cited by this paper
  27. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite · Jill A. McMahon · 1998 · 855 citations · Cited by this paper
  28. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo · Jae‐Hyuck Shim · 2005 · 738 citations · Cited by this paper
  29. Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction · Franck Lebrin · 2004 · 659 citations · Cited by this paper
  30. Global incidence and prevalence of idiopathic pulmonary fibrosis · Toby M. Maher · 2021 · 640 citations · Cited by this paper
  31. Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP · Matthew R. Duncan · 1999 · 632 citations · Cited by this paper
  32. Smad3 as a mediator of the fibrotic response · Kathleen Corey Flanders · 2004 · 608 citations · Cited by this paper
  33. The ERK Cascade: Distinct Functions within Various Subcellular Organelles · Inbal Wortzel · 2011 · 566 citations · Cited by this paper
  34. Developmental pathways in the pathogenesis of lung fibrosis · Diptiman Chanda · 2018 · 540 citations · Cited by this paper
  35. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β · Jiří Zavadil · 2001 · 539 citations · Cited by this paper
  36. Forced Vital Capacity in Patients with Idiopathic Pulmonary Fibrosis: Test Properties and Minimal Clinically Important Difference · Roland M. du Bois · 2011 · 534 citations · Cited by this paper
  37. Novel therapies emerging in oncology to target the TGF-β pathway · Byung‐Gyu Kim · 2021 · 482 citations · Cited by this paper
  38. TGF-β receptors: In and beyond TGF-β signaling · Alexandra Vander Ark · 2018 · 476 citations · Cited by this paper
  39. Pirfenidone for idiopathic pulmonary fibrosis: analysis of pooled data from three multinational phase 3 trials · Paul W. Noble · 2015 · 474 citations · Cited by this paper

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