Research map: GLP1R and GIPR/GLP1R Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction

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  1. Neurobiology of addiction: a neurocircuitry analysis · George F. Koob · 2016 · 3784 citations · Cited by this paper
  2. Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory · 2026 · Related
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  5. Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders · Bridget F. Grant · 2004 · 2907 citations · Cited by this paper
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  11. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. · Michael Albrecht Nauck · 1993 · 1661 citations · Cited by this paper
  12. Do Genetic Variants Directly Shape Population-Level Schizophrenia Burden? A Global Genomic Analysis · 2026 · Related
  13. Metabolism disrupting chemicals and metabolic disorders · Jerrold J. Heindel · 2016 · 1129 citations · Cited by this paper
  14. Prospective Development of a Whole-Brain Connectivity and Electric Field–Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms · 2026 · Related
  15. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis · Toby Pillinger · 2019 · 1082 citations · Cited by this paper
  16. Does Biological Subtyping of Brain Structure in Schizophrenia Bring Us Personalized Psychiatry? · 2026 · Related
  17. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy · Zhikai Zheng · 2024 · 982 citations · Cited by this paper
  18. Treatment approaches for alcohol use disorder with metabolic dysfunction · 2025 · Related
  19. Inhibition of gastric inhibitory polypeptide signaling prevents obesity · Kazumasa Miyawaki · 2002 · 969 citations · Cited by this paper
  20. Alcohol-associated liver disease: A review · 2025 · Related
  21. Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis · Rohit Seth Loomba · 2024 · 942 citations · Cited by this paper
  22. Alcohol Consumption and Obesity: An Update · Gregory Traversy · 2015 · 648 citations · Cited by this paper
  23. Genetic drug target validation using Mendelian randomisation · Amand Floriaan Schmidt · 2020 · 638 citations · Cited by this paper
  24. Diagnosis and Pharmacotherapy of Alcohol Use Disorder · Henry R. Kranzler · 2018 · 595 citations · Cited by this paper
  25. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity · Louis J. Aronne · 2025 · 572 citations · Cited by this paper
  26. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist · Francis S. Willard · 2020 · 541 citations · Cited by this paper
  27. Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) · T-K Clarke · 2017 · 505 citations · Cited by this paper
  28. Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial · Amalia Gastaldelli · 2022 · 504 citations · Cited by this paper
  29. Effects of Moderate Alcohol Intake on Fasting Insulin and Glucose Concentrations and Insulin Sensitivity in Postmenopausal Women · Michael J. Davies · 2002 · 466 citations · Cited by this paper
  30. Chronic diseases and conditions related to alcohol use · Kevin David Shield · 2013 · 458 citations · Cited by this paper
  31. Psychiatric comorbidities in alcohol use disorder · Álvaro Castillo‐Carniglia · 2019 · 453 citations · Cited by this paper
  32. Alcohol Consumption and Risk of Liver Cirrhosis: A Systematic Review and Meta-Analysis · Michael Roerecke · 2019 · 398 citations · Cited by this paper
  33. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways · Olufunto Olayinka Badmus · 2022 · 381 citations · Cited by this paper
  34. Alcohol-associated liver disease · Bryan Mackowiak · 2024 · 349 citations · Cited by this paper
  35. Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake · Alice E. Adriaenssens · 2019 · 330 citations · Cited by this paper
  36. Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease · Fredrik O. Åberg · 2022 · 302 citations · Cited by this paper
  37. The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials · Thinzar Min · 2020 · 284 citations · Cited by this paper
  38. Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis · Thomas Karagiannis · 2022 · 264 citations · Cited by this paper
  39. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder · Christian S. Hendershot · 2025 · 258 citations · Cited by this paper

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