Research map: Overcoming mTOR Inhibitor Resistance: From Biological Basis to Therapeutic Strategies

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  1. Copper induces cell death by targeting lipoylated TCA cycle proteins · Peter Tsvetkov · 2022 · 5027 citations · Cited by this paper
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  7. mTOR signalling and cellular metabolism are mutual determinants in cancer · Dirk Mossmann · 2018 · 1142 citations · Cited by this paper
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  9. Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib · Andrew Xiuxuan Zhu · 2014 · 576 citations · Cited by this paper
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  11. Twenty-five years of mTOR: Uncovering the link from nutrients to growth · David M. Sabatini · 2017 · 516 citations · Cited by this paper
  12. Evolving Landscape of Systemic Therapy for Hepatocellular Carcinoma: From Targeted Therapy and Combination Strategies to Emerging Therapies · 2026 · Related
  13. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial · Fabrice André · 2014 · 496 citations · Cited by this paper
  14. Evaluation of Early and Delayed Meloxicam Treatment Against Regulated Cell Death Pathways and ERK1/2 Phosphorylation in a Rat Model of Renal Ischemia–Reperfusion Injury · 2026 · Related
  15. Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma · Robert John Motzer · 2014 · 433 citations · Cited by this paper
  16. Region-Specific Proteomic Profiles of Extracellular Vesicles (EVs) Derived from Human Macular and Peripheral RPE-Choroid Explants · 2026 · Related
  17. The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism · Lingyu Tian · 2023 · 329 citations · Cited by this paper
  18. Bioactive Metabolites of Solanum tuberosum L. in Inflammation Modulation and Tissue Regeneration: A Scoping Review of Wound Healing Mechanisms · 2026 · Related
  19. Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery · Binfan Chen · 2020 · 161 citations · Cited by this paper
  20. Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway · 2026 · Related
  21. ATF4 and N‐Myc coordinate glutamine metabolism in MYCN ‐amplified neuroblastoma cells through ASCT2 activation · Ping Ren · 2014 · 157 citations · Cited by this paper
  22. Clinical implications of the interaction between PD-1/PD-L1 and PI3K/AKT/mTOR pathway in progression and treatment of non-small cell lung cancer · Zihan Quan · 2022 · 125 citations · Cited by this paper
  23. YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis · Xuemei Yao · 2022 · 111 citations · Cited by this paper
  24. Harnessing machine learning to find synergistic combinations for FDA-approved cancer drugs · Tarek Abd El‐Hafeez · 2024 · 104 citations · Cited by this paper
  25. ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma · Yan Sun · 2023 · 87 citations · Cited by this paper
  26. Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer · Camilla Evangelisti · 2019 · 80 citations · Cited by this paper
  27. Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT / mTOR pathway in prostate cancer · Hongzhuang Wen · 2023 · 79 citations · Cited by this paper
  28. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer · Diane M. Demas · 2019 · 76 citations · Cited by this paper
  29. Everolimus Plus Endocrine Therapy for Postmenopausal Women With Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer · Melanie Royce · 2018 · 72 citations · Cited by this paper
  30. Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors · G. Leslie Burnett · 2022 · 72 citations · Cited by this paper
  31. Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma · Bruna Calsina · 2019 · 71 citations · Cited by this paper
  32. Chromatin and transcriptional regulation by reversible RNA methylation · Jiangbo Wei · 2021 · 67 citations · Cited by this paper
  33. ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells · Danfeng Xue · 2020 · 66 citations · Cited by this paper
  34. mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why? · Shi‐Yong Sun · 2020 · 64 citations · Cited by this paper
  35. The pathogenesis and therapeutic implications of metabolic reprogramming in renal cell carcinoma · Yifan Zhang · 2025 · 60 citations · Cited by this paper
  36. Combining mTOR Inhibitors and T Cell-Based Immunotherapies in Cancer Treatment · A. Hage · 2021 · 50 citations · Cited by this paper
  37. Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors · Xia Qin · 2020 · 49 citations · Cited by this paper
  38. Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling · Jing Cui · 2021 · 49 citations · Cited by this paper
  39. Resistance to Targeted Inhibitors of the PI3K/AKT/mTOR Pathway in Advanced Oestrogen-Receptor-Positive Breast Cancer · Iseult M. Browne · 2024 · 45 citations · Cited by this paper

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