Research map: Methionine Regulates Antitumour Function of CD8 + T Cells Through Polyamine Synthesis

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  17. Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming · Dominic Guy Roy · 2020 · 357 citations · Cited by this paper
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  22. Polyamine metabolism is a central determinant of helper T cell lineage fidelity · Daniel J. Puleston · 2021 · 307 citations · Cited by this paper
  23. Antigen receptor control of methionine metabolism in T cells · Linda V. Sinclair · 2019 · 232 citations · Cited by this paper
  24. Methionine deficiency facilitates antitumour immunity by altering m 6 A methylation of immune checkpoint transcripts · Ting Li · 2022 · 232 citations · Cited by this paper
  25. Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment · Candace S. Hayes · 2013 · 169 citations · Cited by this paper
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  28. RETRACTED: Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity · Lan Fang · 2023 · 124 citations · Cited by this paper
  29. Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy · Ashley R. Orillion · 2018 · 123 citations · Cited by this paper
  30. Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade · Ying Xue · 2023 · 121 citations · Cited by this paper
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  33. Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota · Ming Hua Ji · 2023 · 103 citations · Cited by this paper
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  35. Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response · Cheng-Cheng Yao · 2023 · 92 citations · Cited by this paper
  36. Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells · Mahesh Pandit · 2023 · 81 citations · Cited by this paper
  37. 13 C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells · Eric H. Ma · 2024 · 55 citations · Cited by this paper
  38. A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue · Kyle D. Duncan · 2017 · 53 citations · Cited by this paper
  39. Early methionine availability attenuates T cell exhaustion · Piyush Sharma · 2025 · 38 citations · Cited by this paper

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