Research map: Efficacy of ultraviolet irradiation of pharmaceutical excipients in mitigating N-nitrosamine generation

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Papers in this map

  1. The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine · P N Magee · 1956 · 903 citations · Cited by this paper
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  10. Rational design, expression and refolding of a novel bispecific antibody to simultaneously target VEGF-A and Ang-2 for inhibition of angiogenesis · 2026 · Related
  11. Engineering of cyclodextrin glycosyltransferase reaction and product specificity · Bart A. van der Veen · 2000 · 203 citations · Cited by this paper
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  15. The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals · Joerg Schlingemann · 2022 · 138 citations · Cited by this paper
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  17. Potential for the Formation of N -Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water · Ian W. Ashworth · 2020 · 137 citations · Cited by this paper
  18. Identification of a diastereomer of penicilloic acid during acid-mediated degradation of 6-aminopenicillanic acid · 2026 · Related
  19. Formation of N -Nitrosamine Drug Substance Related Impurities in Medicines: A Regulatory Perspective on Risk Factors and Mitigation Strategies · Răzvan C. Cioc · 2023 · 134 citations · Cited by this paper
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  21. Pathways for N -Nitroso Compound Formation: Secondary Amines and Beyond · Rocío López‐Rodríguez · 2020 · 133 citations · Cited by this paper
  22. A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug Products · Ruth Boetzel · 2022 · 110 citations · Cited by this paper
  23. Oxidation of Drugs during Drug Product Development: Problems and Solutions · Alen Gabrič · 2022 · 106 citations · Cited by this paper
  24. Photo-induced degradation of cellulose · Jasna Malešič · 2005 · 100 citations · Cited by this paper
  25. The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny · Raphael Nudelman · 2023 · 91 citations · Cited by this paper
  26. Photodegradation of Cassava and Corn Starches · Andréa C. Bertolini · 2001 · 88 citations · Cited by this paper
  27. Inhibition of N-Nitrosamine Formation in Drug Products: A Model Study · Kausik K. Nanda · 2021 · 79 citations · Cited by this paper
  28. Regulatory Experiences with Root Causes and Risk Factors for Nitrosamine Impurities in Pharmaceuticals · Stephen Horne · 2023 · 75 citations · Cited by this paper
  29. Photooxidation of poly(N-vinylpyrrolidone) (PVP) in the solid state and in aqueous solution · Fatima Hassouna · 2009 · 74 citations · Cited by this paper
  30. N-Nitrosamine Formation in Pharmaceutical Solid Drug Products: Experimental Observations · Justin D. Moser · 2023 · 68 citations · Cited by this paper
  31. NOx emissions by real-world fresh and old asphalt mixtures: Impact of temperature, relative humidity, and UV-irradiation · Jérôme Lasne · 2023 · 35 citations · Cited by this paper
  32. Statistical comparison of dissolution profiles · Yifan Wang · 2015 · 32 citations · Cited by this paper
  33. Bumetanide as a Model NDSRI Substrate: N-nitrosobumetanide Impurity Formation and its Inhibition in Bumetanide Tablets · Diaá M. Shakleya · 2023 · 27 citations · Cited by this paper
  34. N -Nitrosodimethylamine Formation in Metformin Drug Products by the Reaction of Dimethylamine and Atmospheric NO 2 · Shohei Fukuda · 2023 · 27 citations · Cited by this paper
  35. Methods for Measuring Nitrate Reductase, Nitrite Levels, and Nitric Oxide from Plant Tissues · Aakanksha Wany · 2019 · 26 citations · Cited by this paper
  36. Estimation of acceptable daily intake values based on modeling and in vivo mutagenicity of NDSRIs of fluoxetine, duloxetine and atomoxetine · Robert A. Jolly · 2024 · 23 citations · Cited by this paper
  37. Kinetic studies on the formation of nitrosamines I · J. M. Cachaza · 1978 · 19 citations · Cited by this paper
  38. Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review · Michał Gackowski · 2023 · 19 citations · Cited by this paper
  39. Drug Substance and Drug Product Workflows for Quality Risk Management for the Presence of Nitrosamines in Medicines · Olivier Dirat · 2025 · 16 citations · Cited by this paper

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