Research map: Porphyromonas gingivalis Drives Trained Immunity via the Glycolysis– SIRT1 Axis to Aggravate Colitis

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  1. Trained immunity: A program of innate immune memory in health and disease · Mihai Gheorghe Netea · 2016 · 2828 citations · Cited by this paper
  2. Clinical Outcomes of a Digital Companion in Periodontal Care: A Randomised Controlled Trial · 2026 · Related
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  5. Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement · George Hajishengallis · 2011 · 1168 citations · Cited by this paper
  6. Prognostic Assessment of Tooth Survival After Treatment of Endodontic‐Periodontal Lesions: A Retrospective Study · 2026 · Related
  7. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity · Ioannis Mitroulis · 2018 · 1122 citations · Cited by this paper
  8. Treatment of Residual Pockets in Stage III and IV Periodontitis Using an Oscillating Chitosan Device With or Without a Chitosan Gel—A Randomised Parallel‐Arms Clinical Trial · 2026 · Related
  9. Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells · Arieh Moussaieff · 2015 · 690 citations · Cited by this paper
  10. The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part II : The Evaluation of Clinical and Radiological Parameters in a Randomised Controlled Clinical Trial · 2026 · Related
  11. The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells · James G. Ryall · 2015 · 590 citations · Cited by this paper
  12. Peri‐Implant‐Medication‐Related Osteonecrosis of the Jaws: Epidemiological, Clinical and Radiographic Features—A Retrospective Cohort Study · 2026 · Related
  13. The Intersection of Epigenetics and Metabolism in Trained Immunity · Stephanie Fanucchi · 2020 · 438 citations · Cited by this paper
  14. Large Language Models and Retrieval‐Augmented Platforms for the Diagnosis and Management of Periodontal Diseases: A Blinded Expert‐Rated Comparative Study of 11 Systems · 2026 · Related
  15. Metabolic Regulation of Histone Post-Translational Modifications · Jing Fan · 2015 · 343 citations · Cited by this paper
  16. Association Between Change in Dental Hygiene Practices and Incidence of Dementia · 2026 · Related
  17. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities · Xiaofei Li · 2022 · 326 citations · Cited by this paper
  18. The Dietary Inflammatory Index and Periodontal Inflammation in Community‐Dwelling Older Adults in Japan: The Otassha Study · 2026 · Related
  19. M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity · Nargis Khan · 2020 · 300 citations · Cited by this paper
  20. Probiotics Augment the Effect of Non‐Surgical Periodontal Treatment—A Randomised, Double‐Blinded, Placebo‐Controlled Trial · 2026 · Related
  21. Epigenetics and Trained Immunity · Charlotte D.C.C. van der Heijden · 2017 · 279 citations · Cited by this paper
  22. Regulating histone acetyltransferases and deacetylases · Gaëlle Legube · 2003 · 261 citations · Cited by this paper
  23. Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory · Athanasios Ziogas · 2025 · 158 citations · Cited by this paper
  24. Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment · Xiaoyang Ma · 2023 · 94 citations · Cited by this paper
  25. Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice · Takahiro Tsuzuno · 2021 · 82 citations · Cited by this paper
  26. The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations · Tianyu Zhou · 2023 · 82 citations · Cited by this paper
  27. Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species · Lorena Aguilar‐Arnal · 2016 · 77 citations · Cited by this paper
  28. Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers · Caroline A. de Jongh · 2023 · 66 citations · Cited by this paper
  29. Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation · Minhong Huang · 2023 · 63 citations · Cited by this paper
  30. Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow · Iñaki Robles‐Vera · 2025 · 53 citations · Cited by this paper
  31. Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia · Tandrika Chattopadhyay · 2020 · 51 citations · Cited by this paper
  32. Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+/NADH balance · Jingjing Tang · 2024 · 42 citations · Cited by this paper
  33. Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection · Simon Carlile · 2024 · 20 citations · Cited by this paper
  34. Global prevalence and incidence of inflammatory bowel disease: a systematic review and meta-analysis of population-based studies. · Keyvan Heydari · 2025 · 19 citations · Cited by this paper
  35. Porphyromonas gingivalis ‐Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis · Jiayi Liu · 2024 · 17 citations · Cited by this paper
  36. Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections · Luna Minute · 2025 · 15 citations · Cited by this paper
  37. VBNC, previously unrecognized in the life cycle of Porphyromonas gingivalis? · Ann Progulske‐Fox · 2022 · 14 citations · Cited by this paper
  38. Periodontitis and the Incidence of Inflammatory Bowel Diseases: A Nationwide Population-Based Cohort Study · Yehyun Park · 2025 · 12 citations · Cited by this paper
  39. IFN-I-mediated neutropoiesis bias drives neutrophil priming and inflammatory comorbidities · Yuman Li · 2025 · 7 citations · Cited by this paper

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