Research map: The evolving treatment landscape of restless legs syndrome

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Papers in this map

  1. Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance · Richard P. Allen · 2014 · 1618 citations · Cited by this paper
  2. Narcolepsy with co-occurring epilepsy: diagnostic pitfalls and management strategy · 2026 · Related
  3. Augmentation of the Restless Legs Syndrome With Carbidopa/Levodopa · Richard P. Allen · 1996 · 453 citations · Cited by this paper
  4. Positioning siponimod and the post-treatment gap: the unmet needs of SPMS patients in Italian real-world practice · 2026 · Related
  5. Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report · Richard P. Allen · 2017 · 349 citations · Cited by this paper
  6. Bilateral transcutaneous auricular nerve stimulation promotes motor function recovery after stroke: A randomized controlled trial · 2026 · Related
  7. Guidelines for the first-line treatment of restless legs syndrome/Willis–Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation · Diego Garcı́a-Borreguero · 2016 · 343 citations · Cited by this paper
  8. Novel homozygous SYNE1 missense variant in late onset autosomal recessive cerebellar ataxia 1: a case report · 2026 · Related
  9. Update to the AASM Clinical Practice Guideline: “The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults—An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses” · Rashmi Nisha Aurora · 2012 · 330 citations · Cited by this paper
  10. Psoriasis under B-cell depleting therapies in multiple sclerosis: a retrospective multicenter analysis · 2026 · Related
  11. Diagnostic Standards for Dopaminergic Augmentation of Restless Legs Syndrome: Report from a World Association of Sleep Medicine – International Restless Legs Syndrome Study Group Consensus Conference at the Max Planck Institute · Diego Garcı́a-Borreguero · 2007 · 286 citations · Cited by this paper
  12. Heart rate and clinical outcome after endovascular treatment in patients with anterior versus posterior circulation large vessel occlusion · 2026 · Related
  13. Restless legs syndrome · Mauro Manconi · 2021 · 272 citations · Cited by this paper
  14. Medical cannabis improved self-reported spasticity rating in patients with chronic spinal cord injury: a placebo-controlled, double-blind, crossover pilot clinical trial · 2026 · Related
  15. Comparison of Pregabalin with Pramipexole for Restless Legs Syndrome · Richard P. Allen · 2014 · 241 citations · Cited by this paper
  16. A Delphi consensus on integrating novel therapies into the management of generalized myasthenia gravis · 2026 · Related
  17. Practice guideline summary: Treatment of restless legs syndrome in adults [RETIRED] · John Weyl Winkelman · 2016 · 232 citations · Cited by this paper
  18. Pharmacological Strategies for the Treatment of Restless Legs Syndrome · 2025 · Related
  19. The Management of Restless Legs Syndrome: An Updated Algorithm · Michael H. Silber · 2021 · 204 citations · Cited by this paper
  20. Evaluating the adenosine hypothesis of restless legs syndrome and its implications for current and future treatment strategies · 2025 · Related
  21. Brain Iron Metabolism Dysfunction in Parkinson’s Disease · Hong Fu Jiang · 2016 · 185 citations · Cited by this paper
  22. Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation · Daniel L. Picchietti · 2014 · 176 citations · Cited by this paper
  23. Treatment of restless legs syndrome: Evidence‐based review and implications for clinical practice (Revised 2017)§ · Juliane Winkelmann · 2018 · 173 citations · Cited by this paper
  24. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline · John Weyl Winkelman · 2024 · 163 citations · Cited by this paper
  25. Restless legs syndrome—current therapies and management of augmentation · Claudia Trenkwalder · 2015 · 99 citations · Cited by this paper
  26. Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla · Xu Li · 2016 · 92 citations · Cited by this paper
  27. Ferric carboxymaltose in patients with restless legs syndrome and nonanemic iron deficiency: A randomized trial · Claudia Trenkwalder · 2017 · 74 citations · Cited by this paper
  28. Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction · Barbara Schormair · 2024 · 66 citations · Cited by this paper
  29. Restless legs syndrome: an historical note · G Coccagna · 2004 · 50 citations · Cited by this paper
  30. Long-Term Treatment of Restless Legs Syndrome (RLS): An Approach to Management of Worsening Symptoms, Loss of Efficacy, and Augmentation · Susan E. Mackie · 2015 · 48 citations · Cited by this paper
  31. Pharmacologic Treatment of Restless Legs Syndrome · Qing Lv · 2020 · 33 citations · Cited by this paper
  32. Treating Severe Refractory and Augmented Restless Legs Syndrome · John Weyl Winkelman · 2022 · 33 citations · Cited by this paper
  33. Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis · Maria Paola Mogavero · 2024 · 33 citations · Cited by this paper
  34. Efficacy and safety of tonic motor activation (TOMAC) for medication-refractory restless legs syndrome: a randomized clinical trial · Richard Bogan · 2023 · 32 citations · Cited by this paper
  35. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment · John Weyl Winkelman · 2024 · 31 citations · Cited by this paper
  36. Long-term Safety, Dose Stability, and Efficacy of Opioids for Patients With Restless Legs Syndrome in the National RLS Opioid Registry · John Weyl Winkelman · 2023 · 27 citations · Cited by this paper
  37. Restless Legs Syndrome: A Review. · John Weyl Winkelman · 2026 · 23 citations · Cited by this paper
  38. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome · Arthur Scott Walters · 2023 · 21 citations · Cited by this paper
  39. Jidong Restless Legs Syndrome Cohort Study: Objectives, Design, and Baseline Screening · Shuhong Wang · 2021 · 13 citations · Cited by this paper

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