Research map: Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

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  1. Fat-1 mice convert n-6 to n-3 fatty acids · Jing Xuan Kang · 2004 · 547 citations · Cited by this paper
  2. Reliability of Ultrasonography to Assess Spinal Compression During Heavy Load Carriage · 2026 · Related
  3. Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study · Masatoshi Teraguchi · 2013 · 526 citations · Cited by this paper
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  5. Inflammation in intervertebral disc degeneration and regeneration · Maria Molinos · 2015 · 460 citations · Cited by this paper
  6. In‐Field Ecological Momentary Assessment From Wearable Motion Sensors and Self‐Report in a Chronic Low Back Pain Cohort · 2026 · Related
  7. Degeneration and regeneration of the intervertebral disc: lessons from development · Lachlan J. Smith · 2010 · 415 citations · Cited by this paper
  8. A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology · 2026 · Related
  9. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis · Christian A. Hudert · 2006 · 380 citations · Cited by this paper
  10. Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet) · 2026 · Related
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  12. Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy · 2026 · Related
  13. Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment · Kengo Fujii · 2019 · 184 citations · Cited by this paper
  14. Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration · 2026 · Related
  15. Fat-1 transgenic mice: A new model for omega-3 research · Jing Xuan Kang · 2007 · 179 citations · Cited by this paper
  16. Explainable Supervised Learning Classification Model Using Diffusion Tensor Imaging Predicts Postoperative Outcomes in Cervical Spondylotic Myelopathy: A Preliminary Study · 2026 · Related
  17. Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link? · Clara Ruiz‐Fernández · 2019 · 155 citations · Cited by this paper
  18. Sex Hormones Attenuate Pro‐Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell‐Type Specific Manner · 2026 · Related
  19. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- · Karsten Henrich Weylandt · 2011 · 145 citations · Cited by this paper
  20. The Prognostic Significance of LINC00638 in Lumbar Disc Herniation and Its Effect on Senescence of Nucleus Pulposus Cells · 2025 · Related
  21. Melanoma growth is reduced in fat-1 transgenic mice: Impact of omega-6/omega-3 essential fatty acids · Shuhua Xia · 2006 · 138 citations · Cited by this paper
  22. Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes · Svenja Illien‐Jünger · 2013 · 115 citations · Cited by this paper
  23. Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD‐T2DM rat model of type 2 diabetes · Aaron J. Fields · 2015 · 107 citations · Cited by this paper
  24. Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans · Chao‐Wei Huang · 2016 · 101 citations · Cited by this paper
  25. Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative · Itzel Paola Melgoza · 2021 · 88 citations · Cited by this paper
  26. The impact of age and sex on body composition and glucose sensitivity in C57BL/6J mice · Thomas Reynolds · 2019 · 77 citations · Cited by this paper
  27. Aging of mouse intervertebral disc and association with back pain · Kathleen F. Vincent · 2019 · 73 citations · Cited by this paper
  28. Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration · Zhangfu Li · 2023 · 54 citations · Cited by this paper
  29. Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice · Natalia S. Harasymowicz · 2019 · 52 citations · Cited by this paper
  30. Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury · Siew‐Na Lim · 2012 · 51 citations · Cited by this paper
  31. The Fat-1 Transgene in Mice Increases Antioxidant Potential, Reduces Pro‐Inflammatory Cytokine Levels, and Enhances PPARγ and SIRT‐1 Expression on a Calorie Restricted Diet · Md Mizanur Rahman · 2009 · 42 citations · Cited by this paper
  32. Investigating the Effects of Sex Hormones on Macrophage Polarization · Sophie Enright · 2024 · 38 citations · Cited by this paper
  33. Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis · Ruhang Tang · 2024 · 33 citations · Cited by this paper
  34. Is Obesity a Disease of Stem Cells? · Arin K. Oestreich · 2020 · 31 citations · Cited by this paper
  35. Sex differences in systemic inflammation and immune function in diet‐induced obesity rodent models: A systematic review · Jenneffer Rayane Braga Tibães · 2023 · 30 citations · Cited by this paper
  36. Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model · Devorah M. Natelson · 2020 · 27 citations · Cited by this paper
  37. Relation of lumbar intervertebral disc height and severity of disc degeneration based on Pfirrmann scores · Xiaolong Chen · 2023 · 23 citations · Cited by this paper
  38. Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration · Jeffrey Barr Warner · 2021 · 15 citations · Cited by this paper
  39. The Vicious Cycle of Obesity and Low Back Pain: A Comprehensive Review · Clara Ruiz‐Fernández · 2025 · 15 citations · Cited by this paper

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