Research map: Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis

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  1. Cellpose: a generalist algorithm for cellular segmentation · Carsen Stringer · 2020 · 4690 citations · Cited by this paper
  2. Pyroptotic pores reopen the case for caspase inhibitors · Ivano Amelio · 2026 · Cites this paper
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  18. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf · Sanjeev Mariathasan · 2004 · 1854 citations · Cited by this paper
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  20. Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 · Nobuhiko Kayagaki · 2013 · 1586 citations · Cited by this paper
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  22. TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines · Dmitry Ershov · 2022 · 1338 citations · Cited by this paper
  23. Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock · Jon A. Hagar · 2013 · 1267 citations · Cited by this paper
  24. MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition · Rebecca C. Coll · 2019 · 1049 citations · Cited by this paper
  25. Cell death · Kim I. Newton · 2024 · 988 citations · Cited by this paper
  26. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation · Sebastian Rühl · 2018 · 780 citations · Cited by this paper
  27. Gasdermin D pore structure reveals preferential release of mature interleukin-1 · Shiyu Xia · 2021 · 660 citations · Cited by this paper
  28. Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones · Nancy A. Thornberry · 1994 · 265 citations · Cited by this paper
  29. Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding · Franklin L. Zhong · 2018 · 261 citations · Cited by this paper
  30. Caspase Substrates and Inhibitors · Marcin Poręba · 2013 · 197 citations · Cited by this paper
  31. A long way to go: caspase inhibitors in clinical use · Shanel Dhani · 2021 · 194 citations · Cited by this paper
  32. Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding · Alessia Zamborlini · 2006 · 185 citations · Cited by this paper
  33. Caspases: Preparation and Characterization · Henning R. Stennicke · 1999 · 182 citations · Cited by this paper
  34. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition · Lieselotte Vande Walle · 2019 · 167 citations · Cited by this paper
  35. ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack · Alex T. Ritter · 2022 · 141 citations · Cited by this paper
  36. Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity · Alicia B Berger · 2006 · 128 citations · Cited by this paper
  37. Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD · Rosalie Heilig · 2020 · 126 citations · Cited by this paper
  38. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity · Marcin Poręba · 2017 · 110 citations · Cited by this paper
  39. First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease · Steven D. Linton · 2005 · 107 citations · Cited by this paper

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