Research map: Metabolic Regulation of Macrophages in Health and Disease

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  1. Macrophage biology in development, homeostasis and disease · Thomas A. Wynn · 2013 · 4823 citations · Cited by this paper
  2. Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management · 2026 · Related
  3. Metabolic regulation of gene expression by histone lactylation · Di Zhang · 2019 · 4375 citations · Cited by this paper
  4. Preoperative Albumin Infusion Reduced Pulmonary Complications in Elderly Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Single‐Center, Randomized, Double‐Blind, Controlled Pilot Trial · 2026 · Related
  5. Succinate is an inflammatory signal that induces IL-1β through HIF-1α · Gillian M. Tannahill · 2013 · 4209 citations · Cited by this paper
  6. CD8 + Tissue‐Resident Memory T Cells in Health and Disease · 2026 · Related
  7. M-1/M-2 Macrophages and the Th1/Th2 Paradigm · Charles Dudley Mills · 2000 · 3343 citations · Cited by this paper
  8. MYC in Oncogenesis and Therapeutic Implications · 2026 · Related
  9. The JAK/STAT signaling pathway: from bench to clinic · Xiaoyi Hu · 2021 · 2632 citations · Cited by this paper
  10. Lymphatic Endothelial Cells in Health and Disease · 2026 · Related
  11. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors · Elisa Gomez Perdiguero · 2014 · 2387 citations · Cited by this paper
  12. Nicotinamide N‐Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma · 2026 · Related
  13. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages · Evanna L. Mills · 2016 · 2327 citations · Cited by this paper
  14. Markers Predicting Cure With Combinatorial Treatment in a Mouse Model of Latent Autoimmune Diabetes in Adults · 2026 · Related
  15. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity · Sydney R. Gordon · 2017 · 2327 citations · Cited by this paper
  16. Safety and Efficacy of Aumolertinib as First‐Line Treatment in EGFR‐Mutant Lung Adenosquamous Carcinoma: A Multicenter, Single‐Arm, Prospective Phase II Study (ARISE Study) · 2026 · Related
  17. Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment · Yonit Lavin · 2014 · 2253 citations · Cited by this paper
  18. Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis · 2026 · Related
  19. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance · Justin Iver Odegaard · 2007 · 2117 citations · Cited by this paper
  20. Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers · 2026 · Related
  21. Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization · Abhishek Jha · 2015 · 2088 citations · Cited by this paper
  22. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024 · Nuha A. ElSayed · 2023 · 2018 citations · Cited by this paper
  23. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 · Evanna L. Mills · 2018 · 1944 citations · Cited by this paper
  24. Human chimeric antigen receptor macrophages for cancer immunotherapy · Michael Klichinsky · 2020 · 1499 citations · Cited by this paper
  25. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy · Amira A. Barkal · 2019 · 1438 citations · Cited by this paper
  26. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages · Eva M. Pålsson‐McDermott · 2015 · 1430 citations · Cited by this paper
  27. Alveolar macrophages: plasticity in a tissue-specific context · Tracy Hussell · 2014 · 1424 citations · Cited by this paper
  28. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation · Divya Vats · 2006 · 1380 citations · Cited by this paper
  29. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial · Paul M. Ridker · 2017 · 1362 citations · Cited by this paper
  30. α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming · Pu-Ste Liu · 2017 · 1273 citations · Cited by this paper
  31. Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches · Svetoslav Chakarov · 2019 · 1179 citations · Cited by this paper
  32. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets · Grant Raymond Drummond · 2011 · 902 citations · Cited by this paper
  33. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity · Kebria Hezaveh · 2022 · 765 citations · Cited by this paper
  34. Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation · Stanley Ching‐Cheng Huang · 2016 · 703 citations · Cited by this paper
  35. Amino Assets: How Amino Acids Support Immunity · Beth L. Kelly · 2020 · 668 citations · Cited by this paper
  36. Metabolic Regulation of Macrophage Polarization in Cancer · Kamiya Mehla · 2019 · 660 citations · Cited by this paper
  37. The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism · Arvand Haschemi · 2012 · 650 citations · Cited by this paper
  38. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells · María Casanova-Acebes · 2021 · 622 citations · Cited by this paper
  39. Orchestration of Metabolism by Macrophages · Subhra Kumar Biswas · 2012 · 600 citations · Cited by this paper

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