Research map: An updated patent review of STAT6 inhibitors and modulators (2020 – present)

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Papers in this map

  1. The JAK/STAT signaling pathway: from bench to clinic · Xiaoyi Hu · 2021 · 2632 citations · Cited by this paper
  2. JAKS AND STATS: Biological Implications · Warren J. Leonard · 1998 · 1835 citations · Cited by this paper
  3. Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells · Mark H. Kaplan · 1996 · 1646 citations · Cited by this paper
  4. THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions · Keats A Nelms · 1999 · 1554 citations · Cited by this paper
  5. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene · Kazuya Shimoda · 1996 · 1299 citations · Cited by this paper
  6. JAK-STAT Signaling: From Interferons to Cytokines · Christian Schindler · 2007 · 1277 citations · Cited by this paper
  7. An Interleukin-4-Induced Transcription Factor: IL-4 Stat · Jinzhao Hou · 1994 · 867 citations · Cited by this paper
  8. Defective STAT signaling by the leptin receptor in diabetic mice. · Nico Ghilardi · 1996 · 807 citations · Cited by this paper
  9. JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression · Katie L. Owen · 2019 · 755 citations · Cited by this paper
  10. IL-13 receptors and signaling pathways: An evolving web · Gurjit K. Khurana Hershey · 2003 · 619 citations · Cited by this paper
  11. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors · Juliann Chmielecki · 2013 · 612 citations · Cited by this paper
  12. Transcriptional regulation by STAT6 · Shreevrat Goenka · 2011 · 437 citations · Cited by this paper
  13. Regulation of inflammation by interleukin-4: a review of “alternatives” · Irina G. Luzina · 2012 · 355 citations · Cited by this paper
  14. Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis · Frederick W. Quelle · 1995 · 335 citations · Cited by this paper
  15. Commentary: IL-4 and IL-13 receptors and signaling · Sarah M. McCormick · 2015 · 332 citations · Cited by this paper
  16. The biology of Stat4 and Stat6 · Andrea L. Wurster · 2000 · 311 citations · Cited by this paper
  17. Signaling mechanisms, interaction partners, and target genes of STAT6 · Daniel Hebenstreit · 2006 · 308 citations · Cited by this paper
  18. Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6 · Thomas Mikita · 1996 · 278 citations · Cited by this paper
  19. Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4 · Helen Kotanides · 1993 · 256 citations · Cited by this paper
  20. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma · Chrystelle Guiter · 2004 · 199 citations · Cited by this paper
  21. Structure, binding, and antagonists in the IL-4/IL-13 receptor system · Thomas D. Mueller · 2002 · 197 citations · Cited by this paper
  22. Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer · Omar M. Rahal · 2017 · 172 citations · Cited by this paper
  23. Kit and FcϵRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells · Thomas R. Hundley · 2004 · 159 citations · Cited by this paper
  24. Therapeutic Targeting of the JAK / STAT Pathway · Saara Aittomäki · 2013 · 152 citations · Cited by this paper
  25. Activating STAT6 mutations in follicular lymphoma · Mehmet Ali Yıldız · 2014 · 151 citations · Cited by this paper
  26. Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias · Mustafa Beneklı · 2009 · 138 citations · Cited by this paper
  27. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease · Mehul Sharma · 2023 · 122 citations · Cited by this paper
  28. STAT6: its role in interleukin 4-mediated biological functions · Kiyoshi Takeda · 1997 · 118 citations · Cited by this paper
  29. Molecular cloning of a cDNA encoding the human interleukin 4 receptor · Jean-Pierre Galizzl · 1990 · 118 citations · Cited by this paper
  30. The essential adaptors of innate immune signaling · Huihui Chen · 2012 · 117 citations · Cited by this paper
  31. Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: A cellular signal for hypertrophy in cardiac muscle · Eduardo J. Mascareno · 1998 · 116 citations · Cited by this paper
  32. Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells · Jian‐Zhong Qin · 2001 · 115 citations · Cited by this paper
  33. STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology · Georgia Karpathiou · 2021 · 115 citations · Cited by this paper
  34. The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology · Natalie A. Sims · 2020 · 95 citations · Cited by this paper
  35. Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations · Bin Xu · 2020 · 86 citations · Cited by this paper
  36. Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression · Akio Masuda · 2001 · 84 citations · Cited by this paper
  37. IL‐13 and IL‐1β promote lung fibroblast growth through coordinated up‐regulation of PDGF‐AA and PDGF‐Rα · Jennifer L. Ingram · 2004 · 82 citations · Cited by this paper
  38. Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts · Bharvin K.R. Patel · 1996 · 76 citations · Cited by this paper
  39. Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells · Kaoru Saijo · 1997 · 73 citations · Cited by this paper

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