Research map: γδ T Cells as a Platform for Immunotherapy: From Biological Principles to Clinical Translation

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Papers in this map

  1. IL-17 and IL-17-producing cells in protection versus pathology · Kingston H. G. Mills · 2022 · 1020 citations · Cited by this paper
  2. Lactylation-Mediated METTL14 Promotes Glycolysis Through Facilitating PGAM1 m6A Methylation in Non-Small Cell Lung Cancer · 2026 · Related
  3. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells · Chengcheng Jin · 2019 · 980 citations · Cited by this paper
  4. Mechanisms and Therapeutic Targeting of the Gut Microbiota-Immune-Brain Axis in Alzheimer’s Disease · 2026 · Related
  5. c-Jun overexpression in CAR T cells induces exhaustion resistance · Rachel C. Lynn · 2019 · 921 citations · Cited by this paper
  6. Differences in Shared T Cell receptor α Repertoire Associated with Recognition of Viral Antigens · 2026 · Related
  7. γδ T cells in cancer · Bruno Silva‐Santos · 2015 · 563 citations · Cited by this paper
  8. Astragalus Polysaccharide Promotes NLRP3 + Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma · 2026 · Related
  9. Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18 · Biliang Hu · 2017 · 508 citations · Cited by this paper
  10. The STING-Inflammasome Axis: Coordinated Immune Regulation and Therapeutic Potential Across Diverse Diseases · 2026 · Related
  11. γδ T cells in homeostasis and host defence of epithelial barrier tissues · Morten Milek Nielsen · 2017 · 495 citations · Cited by this paper
  12. UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylation and Degradation of NLRP3 · 2026 · Related
  13. Engineered exosomes from different sources for cancer-targeted therapy · Menghui H. Zhang · 2023 · 464 citations · Cited by this paper
  14. Numb Mediates IL–1β/TGF–β1–Driven Inflammation–Fibrosis Coupling in Idiopathic Pulmonary Fibrosis · 2026 · Related
  15. Coeliac disease · Markku Mäki · 1997 · 433 citations · Cited by this paper
  16. Pharmacological Modulation of Immunosenescence and Inflammaging: Senolytics, Senomorphics, and Emerging Therapies · 2026 · Related
  17. Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies · Zsolt Sebestyén · 2019 · 430 citations · Cited by this paper
  18. Riboflavin Modulates Complement Activation, Immune Cell Viability and Activation, and Neutrophil Microbicidal Functions in Vitro · 2026 · Related
  19. γδ T cells: origin and fate, subsets, diseases and immunotherapy · Yi Hu · 2023 · 379 citations · Cited by this paper
  20. Epidermodysplasia Verruciformis and Vδ2 γδ T-cell Expansion in STK4 Deficiency · 2024 · Related
  21. The emerging roles of γδ T cells in cancer immunotherapy · Sofia Mensurado · 2023 · 351 citations · Cited by this paper
  22. Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge · Daniel Grant Pellicci · 2020 · 322 citations · Cited by this paper
  23. Cancer immunotherapy with γδ T cells: many paths ahead of us · Dieter Kabelitz · 2020 · 300 citations · Cited by this paper
  24. In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients · Serena Meraviglia · 2010 · 296 citations · Cited by this paper
  25. Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer · Yan Xu · 2020 · 266 citations · Cited by this paper
  26. How transcription factors drive choice of the T cell fate · Hiroyuki Hosokawa · 2020 · 263 citations · Cited by this paper
  27. Emerging role of exosomes in cancer therapy: progress and challenges · Jiale Li · 2025 · 248 citations · Cited by this paper
  28. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease · Toufic Mayassi · 2019 · 200 citations · Cited by this paper
  29. Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma · Amani Makkouk · 2021 · 197 citations · Cited by this paper
  30. Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future · José Saura‐Esteller · 2022 · 195 citations · Cited by this paper
  31. A genome-scale screen for synthetic drivers of T cell proliferation · Mateusz Legut · 2022 · 191 citations · Cited by this paper
  32. Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor · Drew C. Deniger · 2013 · 184 citations · Cited by this paper
  33. γδ T cells for cancer immunotherapy · Jonathan P.H. Fisher · 2014 · 177 citations · Cited by this paper
  34. Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells · Martin Wilhelm · 2014 · 144 citations · Cited by this paper
  35. NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer · Joanna Mikulak · 2019 · 144 citations · Cited by this paper
  36. Next-Generation Cancer Immunotherapy Targeting Glypican-3 · Yasuhiro Shimizu · 2019 · 141 citations · Cited by this paper
  37. Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors · Jang Hyun Park · 2021 · 135 citations · Cited by this paper
  38. Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma · Nekisa Zakeri · 2022 · 135 citations · Cited by this paper
  39. γδ T Lymphocytes: An Effector Cell in Autoimmunity and Infection · Carolina Maiumi Shiromizu · 2018 · 133 citations · Cited by this paper

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