Research map: Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism

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  1. Tirzepatide Once Weekly for the Treatment of Obesity · Ania M. Jastreboff · 2022 · 3661 citations · Cited by this paper
  2. Appetite-suppressing effects of GIPR agonism and antagonism work through different brain regions · Olivia Tysoe · 2026 · Cites this paper
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  4. Inhibition of gastric inhibitory polypeptide signaling prevents obesity · Kazumasa Miyawaki · 2002 · 969 citations · Cited by this paper
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  10. Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake · Alice E. Adriaenssens · 2019 · 330 citations · Cited by this paper
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  12. The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling · Qian Zhang · 2021 · 321 citations · Cited by this paper
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  14. Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism · Piotr A. Mroz · 2018 · 232 citations · Cited by this paper
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  16. Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion · Helen E. Parker · 2012 · 216 citations · Cited by this paper
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  18. GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist–Induced Nausea and Emesis in Preclinical Models · Tito Borner · 2021 · 199 citations · Cited by this paper
  19. Association of GLP-1RA discontinuation and risk of depressive and anxiety disorders in people with type 2 diabetes: a cohort study · 2026 · Related
  20. Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice · Arkadiusz Damian Liśkiewicz · 2023 · 111 citations · Cited by this paper
  21. Reclassification of basic experimental studies in humans — a case for a new publishing consensus · 2026 · Related
  22. PPG neurons of the lower brain stem and their role in brain GLP-1 receptor activation · Stefan Trapp · 2015 · 104 citations · Cited by this paper
  23. Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet–Fed Mice · Erina Joo · 2017 · 98 citations · Cited by this paper
  24. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial · Ania M. Jastreboff · 2025 · 96 citations · Cited by this paper
  25. Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation · Alessia Costa · 2021 · 82 citations · Cited by this paper
  26. Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding · Alice E. Adriaenssens · 2023 · 78 citations · Cited by this paper
  27. GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior · Ricardo J. Samms · 2022 · 71 citations · Cited by this paper
  28. A brainstem circuit for nausea suppression · Chuchu Zhang · 2022 · 71 citations · Cited by this paper
  29. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems · Bin S. Yang · 2022 · 55 citations · Cited by this paper
  30. Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes · Hüsün Sheyma Kizilkaya · 2021 · 52 citations · Cited by this paper
  31. GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice · Robert M. Gutgesell · 2025 · 49 citations · Cited by this paper
  32. A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus · Christopher A. Smith · 2022 · 47 citations · Cited by this paper
  33. Estradiol regulates daily rhythms underlying diet-induced obesity in female mice · Oluwabukola B. Omotola · 2019 · 41 citations · Cited by this paper
  34. Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons · Anthony H. K. Tsang · 2020 · 41 citations · Cited by this paper
  35. GIP receptor agonism blocks chemotherapy-induced nausea and vomiting · Tito Borner · 2023 · 38 citations · Cited by this paper
  36. Stimulating intestinal GIP release reduces food intake and body weight in mice · Jo Edward Lewis · 2024 · 33 citations · Cited by this paper
  37. GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice · Clarissa M. Liu · 2025 · 33 citations · Cited by this paper
  38. Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss · Jordan Wean · 2024 · 27 citations · Cited by this paper
  39. Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice · Jo Edward Lewis · 2022 · 26 citations · Cited by this paper

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