Research map: CerS2/ceramide C24:1/ROCK2 signaling-mediated angiogenesis protects against ischemic brain injury in mice

Back to the article

Papers in this map

  1. The Protein Data Bank · Helen Miriam Berman · 2000 · 40599 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
  3. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading · Oleg Trott · 2009 · 38809 citations · Cited by this paper
  4. Targeting RIPK1 for the treatment of depression: From neuroinflammation to synaptic plasticity · 2026 · Related
  5. PubChem BioAssay: 2017 update · Yanli Wang · 2016 · 694 citations · Cited by this paper
  6. BiP-engaging xanthones from the mangosteen (Garcinia mangostana) induce androgen receptor degradation in prostate cancer cells · 2026 · Related
  7. Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics · Hao-Ran Jin · 2023 · 474 citations · Cited by this paper
  8. Advanced therapy medicinal products for local treatment using new delivery methods · 2026 · Related
  9. CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance · Suryaprakash Raichur · 2014 · 462 citations · Cited by this paper
  10. Core genes drive treatment resistance in triple-negative breast cancer: characteristics, mechanisms, intervention strategies · 2026 · Related
  11. Sphingolipids and phospholipids in insulin resistance and related metabolic disorders · Peter J. Meikle · 2016 · 441 citations · Cited by this paper
  12. HDAC1-mediated PKM2 delactylation modification regulates CIRP-induced angiogenesis in rheumatoid arthritis · 2026 · Related
  13. Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology · Ewelina Józefczuk · 2020 · 223 citations · Cited by this paper
  14. Orforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling · 2026 · Related
  15. Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke · Anja Nitzsche · 2020 · 150 citations · Cited by this paper
  16. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  17. In vivo effects of vascular endothelial growth factor on the chicken chorioallantoic membrane · J�rg Wilting · 1993 · 147 citations · Cited by this paper
  18. Quercetin induces ferroptosis in ovarian cancer by suppressing the NRF2/HO‑1/GPX4 axis and increasing the efficacy of cisplatin · 2026 · Related
  19. Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation · Guannan Li · 2022 · 108 citations · Cited by this paper
  20. MYH11 upregulation attenuates autophagy dysfunction through modulation of ATG4A in metabolic dysfunction-associated steatotic liver disease · 2026 · Related
  21. Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke · Yang Liu · 2021 · 97 citations · Cited by this paper
  22. ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma · Yan Sun · 2023 · 87 citations · Cited by this paper
  23. Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke · Dirk Matthias Hermann · 2022 · 77 citations · Cited by this paper
  24. Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression · Xiangpeng Tan · 2023 · 73 citations · Cited by this paper
  25. Fasudil-induced hypoxia-inducible factor-1α degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells · Keiko Takata · 2008 · 47 citations · Cited by this paper
  26. Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells · Donna C. Kennedy · 2021 · 43 citations · Cited by this paper
  27. VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation · Sanjid Shahriar · 2024 · 38 citations · Cited by this paper
  28. A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure · Marco Benevento · 2024 · 35 citations · Cited by this paper
  29. Bioconjugation Strategies for Revealing the Roles of Lipids in Living Cells · Caroline H. Knittel · 2022 · 28 citations · Cited by this paper
  30. SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy · Anna Kovilakath · 2024 · 22 citations · Cited by this paper
  31. Ying and Yang of Ceramide in the Vascular Endothelium · Gopika SenthilKumar · 2024 · 22 citations · Cited by this paper
  32. A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients · Xin‐Cheng Mao · 2023 · 21 citations · Cited by this paper
  33. Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation · Qiang Li · 2024 · 20 citations · Cited by this paper
  34. Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation · Yi Wu · 2024 · 20 citations · Cited by this paper
  35. Changing genes, cells and networks to reprogram the brain after stroke · Wenlu Li · 2025 · 19 citations · Cited by this paper
  36. Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides · Magali Trayssac · 2021 · 18 citations · Cited by this paper
  37. UPLC-HRMS based metabolomics reveals the sphingolipids with long fatty chains and olefinic bonds up-regulated in metabolic pathway for hypoxia preconditioning · Tao Zhou · 2015 · 17 citations · Cited by this paper
  38. Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway · Yixiang Jiang · 2025 · 17 citations · Cited by this paper
  39. VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis · Cheng‐Hsiang Kuo · 2021 · 16 citations · Cited by this paper

Source: OpenAlex (CC0)