Research map: MARCH8 inhibits PRRSV-2 replication by targeting viral GP5 for proteasomal degradation at a conserved lysine 163

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  1. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method · Kenneth J. Livak · 2001 · 185110 citations · Cited by this paper
  2. YgeP, a global regulator within the ETT2 pathogenicity island, coordinates motility-biofilm balance and negatively controls serum resistance in avian pathogenic Escherichia coli · 2026 · Related
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  11. MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation · Craig A. Eyster · 2011 · 138 citations · Cited by this paper
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  13. Inhibition of MHC Class II Expression and Immune Responses by c-MIR · Mari Ohmura‐Hoshino · 2006 · 134 citations · Cited by this paper
  14. African swine fever virus E301R protein promotes RIG-I autophagic degradation by enhancing RIG-I-sequestosome-1 interaction · 2026 · Related
  15. The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation · Rui Chen · 2012 · 121 citations · Cited by this paper
  16. HtpsB, a type II histidine triad protein of Streptococcus suis, contributes to bacterial virulence and blood-brain barrier disruption · 2026 · Related
  17. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes · Xiaoman Liu · 2021 · 98 citations · Cited by this paper
  18. A novel oral prodrug (CK301) for effusive feline infectious peritonitis: An open-label study evaluating dose optimization and therapeutic efficacy · 2026 · Related
  19. GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) as a target for homologous and broadly neutralizing antibodies · L Popescu · 2017 · 97 citations · Cited by this paper
  20. Tracheal transcriptional response to challenge with virulent Mycoplasma gallisepticum in chickens spray vaccinated with the Vaxsafe MG304 live-attenuated vaccine · 2026 · Related
  21. Overview of the membrane-associated RING-CH (MARCH) E3 ligase family · Johannes H. Bauer · 2016 · 88 citations · Cited by this paper
  22. Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection · Yanzhao Zhang · 2019 · 67 citations · Cited by this paper
  23. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment · Sathish Kumar · 2019 · 63 citations · Cited by this paper
  24. 2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8 · Dage Sun · 2021 · 62 citations · Cited by this paper
  25. MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation · Changqing Yu · 2020 · 56 citations · Cited by this paper
  26. Progress in PRRSV Infection and Adaptive Immune Response Mechanisms · Huanchang Cai · 2023 · 55 citations · Cited by this paper
  27. Aminopeptidase N Is an Entry Co-factor Triggering Porcine Deltacoronavirus Entry via an Endocytotic Pathway · Yuelin Yang · 2021 · 54 citations · Cited by this paper
  28. Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus · Qin Luo · 2023 · 54 citations · Cited by this paper
  29. Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection · Tong-Yun Wang · 2018 · 53 citations · Cited by this paper
  30. MARCH8 inhibits viral infection by two different mechanisms · Yanzhao Zhang · 2020 · 53 citations · Cited by this paper
  31. The HLA-DRα Chain Is Modified by Polyubiquitination · Nicolas Lapaque · 2008 · 52 citations · Cited by this paper
  32. Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins · Cheng Man Lun · 2021 · 51 citations · Cited by this paper
  33. Lactate-lactylation-HSPA6 axis promotes PRRSV replication by impairing IFN-β production · Yu Pang · 2023 · 43 citations · Cited by this paper
  34. The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication · Shuang Zhang · 2023 · 41 citations · Cited by this paper
  35. Elucidating the Antiviral Mechanism of Different MARCH Factors · Supawadee Umthong · 2021 · 40 citations · Cited by this paper
  36. MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells · Fernando Villalón‐Letelier · 2021 · 32 citations · Cited by this paper
  37. Prevalence, Time of Infection, and Diversity of Porcine Reproductive and Respiratory Syndrome Virus in China · Chaosi Li · 2024 · 28 citations · Cited by this paper
  38. Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage · Changqing Yu · 2023 · 25 citations · Cited by this paper
  39. The emerging roles of MARCH8 in viral infections: A double-edged Sword · Changqing Yu · 2023 · 23 citations · Cited by this paper

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