Research map: The PTM Switches of HBx: Master Regulators of HBV Infection and Liver Oncogenesis

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Papers in this map

  1. Breaking the chains: structure and function of the deubiquitinases · David Komander · 2009 · 2137 citations · Cited by this paper
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  21. Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication · Christopher M. Murphy · 2016 · 326 citations · Cited by this paper
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  26. The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection · Congrong Niu · 2017 · 159 citations · Cited by this paper
  27. Pin1 Interacts With a Specific Serine-Proline Motif of Hepatitis B Virus X-Protein to Enhance Hepatocarcinogenesis · Roberta W. C. Pang · 2006 · 132 citations · Cited by this paper
  28. Role of HBx in hepatitis B virus persistence and its therapeutic implications · Betty L. Slagle · 2018 · 119 citations · Cited by this paper
  29. Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus · Kristopher Montrose · 2014 · 94 citations · Cited by this paper
  30. Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation · Guangyun Tan · 2019 · 74 citations · Cited by this paper
  31. Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis · Young‐Suk Yoo · 2019 · 54 citations · Cited by this paper
  32. E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation · Yahui Song · 2021 · 49 citations · Cited by this paper
  33. Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure · Efthymios P. Tsounis · 2021 · 46 citations · Cited by this paper
  34. 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1 · Zhanfei Chen · 2020 · 37 citations · Cited by this paper
  35. Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc5/6 · Lise Rivière · 2019 · 33 citations · Cited by this paper
  36. Id-1 Induces Proteasome-dependent Degradation of the HBX Protein · Ming‐Tat Ling · 2007 · 30 citations · Cited by this paper
  37. Interactome Map Reveals Phospholipid Scramblase 1 as a Novel Regulator of Hepatitis B Virus X Protein · Yanzhi Yuan · 2014 · 27 citations · Cited by this paper
  38. TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition · Hongxiao Song · 2023 · 25 citations · Cited by this paper
  39. Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma · Chi-Wai Cheng · 2020 · 24 citations · Cited by this paper

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