Research map: Cardiomyocyte OTUD7b drives diabetic cardiomyopathy via deubiquitinating and stabilizing TAK1

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Papers in this map

  1. Inflammatory Mediators and the Failing Heart · Douglas L. Mann · 2002 · 999 citations · Cited by this paper
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  15. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3 · Hongbo Hu · 2013 · 229 citations · Cited by this paper
  16. Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation · 2026 · Related
  17. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling · Bin Wang · 2017 · 200 citations · Cited by this paper
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  19. Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β–triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination · Qi Li · 2011 · 196 citations · Cited by this paper
  20. Structural basis for dual targeting of μ-opioid and nociceptin/orphanin FQ receptors by Cebranopadol · 2026 · Related
  21. Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation · Li Zhang · 2011 · 195 citations · Cited by this paper
  22. Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling · Nicholas Paquette · 2012 · 187 citations · Cited by this paper
  23. Post-Translational Modifications of the TAK1-TAB Complex · Yusuke Hirata · 2017 · 161 citations · Cited by this paper
  24. Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis · Meng Zhang · 2021 · 155 citations · Cited by this paper
  25. Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions · Jin‐Ling Huo · 2023 · 144 citations · Cited by this paper
  26. USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart · Saiyang Xie · 2023 · 138 citations · Cited by this paper
  27. Diabetic cardiomyopathy: Clinical phenotype and practice · Xudong Zhao · 2022 · 119 citations · Cited by this paper
  28. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1 · Lin Wang · 2021 · 108 citations · Cited by this paper
  29. Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling · Takeshi Suetomi · 2019 · 104 citations · Cited by this paper
  30. OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity · Weihong Xie · 2022 · 96 citations · Cited by this paper
  31. Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling · Jingjing Zeng · 2023 · 87 citations · Cited by this paper
  32. ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy · Xiangling Xiao · 2023 · 87 citations · Cited by this paper
  33. FoxO1 inhibits autophagosome-lysosome fusion leading to endothelial autophagic-apoptosis in diabetes · Hui Zhang · 2019 · 70 citations · Cited by this paper
  34. TAK1 is an essential kinase for STING trafficking · Mingtong Ma · 2023 · 60 citations · Cited by this paper
  35. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation · I‐Ting Chen · 2015 · 56 citations · Cited by this paper
  36. TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation · Yihui Fan · 2010 · 51 citations · Cited by this paper
  37. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury · Ying‐Yong Zhao · 2024 · 51 citations · Cited by this paper
  38. TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation · Li Liang · 2012 · 44 citations · Cited by this paper
  39. OTUD7B suppresses Smac mimetic-induced lung cancer cell invasion and migration via deubiquitinating TRAF3 · Boxiang Zhang · 2020 · 42 citations · Cited by this paper

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