Research map: ADORA2A activation restores lysosomal function and photoreceptor outer segment degradation in stressed retinal pigment epithelium

Back to the article

Papers in this map

  1. Age-related macular degeneration · Paul Mitchell · 2018 · 1604 citations · Cited by this paper
  2. A Compensatory-Topology and Relay-Gating Graph Network for multimodal stroke rehabilitation assessment · 2026 · Related
  3. Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex · Imran Ahmed Bhutto · 2012 · 1017 citations · Cited by this paper
  4. Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions · 2026 · Related
  5. Pharmacology of Adenosine Receptors: The State of the Art · Pier Andrea Borea · 2018 · 790 citations · Cited by this paper
  6. Placental SNV rs8192446 in the ADORA2A gene is associated with Preeclampsia: a pilot study · 2026 · Related
  7. Age-Related Macular Degeneration · Monika Fleckenstein · 2024 · 537 citations · Cited by this paper
  8. Analysis of factors associated with physical activity in patients with acute pancreatitis: a cross-sectional study in China · 2026 · Related
  9. The cell biology of the retinal pigment epithelium · Aparna Lakkaraju · 2020 · 437 citations · Cited by this paper
  10. The effect of an 8-week Life Kinetics exercise program on salivary cortisol, alpha-amylase, and ımmunoglobulin-A in U14 female cross-country skiers · 2026 · Related
  11. Autophagy in age-related macular degeneration · Kai Kaarniranta · 2022 · 247 citations · Cited by this paper
  12. Association between KCNC1 gene polymorphisms and interindividual variability in aerobic capacity following high-intensity interval training · 2026 · Related
  13. Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms · Shreya Somasundaran · 2020 · 194 citations · Cited by this paper
  14. Growth, physiological, antioxidants, and immune response of heteroclarias catfish fingerlings, to dietary Moringa oleifera leaves extract and its susceptibility to Aeromonas hydrophila infection · 2026 · Related
  15. Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling · Whijin Kwon · 2020 · 155 citations · Cited by this paper
  16. Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women · 2026 · Related
  17. Restoration of Lysosomal pH in RPE Cells from Cultured Human and ABCA4 −/− Mice: Pharmacologic Approaches and Functional Recovery · Ji Liu · 2008 · 141 citations · Cited by this paper
  18. Inactivation of interleukin-15 reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice · 2026 · Related
  19. Age-Related Macular Degeneration, a Mathematically Tractable Disease · Christine A. Curcio · 2024 · 90 citations · Cited by this paper
  20. Exercise-induced pulse pressure augmentation is positively associated with exercise capacity in patients after transcatheter aortic valve implantation · 2026 · Related
  21. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model · Ruchi Sharma · 2021 · 80 citations · Cited by this paper
  22. RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye · Luis Muniz-Feliciano · 2017 · 77 citations · Cited by this paper
  23. Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration · Anne Senabouth · 2022 · 73 citations · Cited by this paper
  24. Autophagy in the retinal pigment epithelium: a new vision and future challenges · Daniela Intartaglia · 2021 · 65 citations · Cited by this paper
  25. Rescue of Compromised Lysosomes Enhances Degradation of Photoreceptor Outer Segments and Reduces Lipofuscin-Like Autofluorescence in Retinal Pigmented Epithelial Cells · Sonia Guha · 2014 · 63 citations · Cited by this paper
  26. Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration · Jongmin Kim · 2021 · 54 citations · Cited by this paper
  27. A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner · Yuichi Saito · 2020 · 47 citations · Cited by this paper
  28. Human retinal pigment epithelial cells in culture possess A2-adenosine receptors · Zvi Friedman · 1989 · 43 citations · Cited by this paper
  29. Lysosomes in retinal health and disease · Patricia Boya · 2023 · 43 citations · Cited by this paper
  30. Eye on the horizon: The metabolic landscape of the RPE in aging and disease · David Hansman · 2024 · 41 citations · Cited by this paper
  31. Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells · Elke Katrin Markert · 2022 · 38 citations · Cited by this paper
  32. Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond · Yu. V. Markitantova · 2025 · 33 citations · Cited by this paper
  33. Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients · Viivi Karema-Jokinen · 2023 · 21 citations · Cited by this paper
  34. Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium · Jessica Y.W. · 2023 · 20 citations · Cited by this paper
  35. Autophagy in dry AMD: A promising therapeutic strategy for retinal pigment epithelial cell damage · Zhao Zhang · 2024 · 16 citations · Cited by this paper
  36. HUNK Phosphorylates Rubicon to Support Autophagy · Joelle N. Zambrano · 2019 · 15 citations · Cited by this paper
  37. Age-related macular degeneration · Robyn H. Guymer · 2014 · 13 citations · Cited by this paper
  38. Phagocytosis by the retinal pigment epithelium: New insights into polarized cell mechanics · Ceniz Zihni · 2024 · 10 citations · Cited by this paper
  39. Roles of class III phosphatidylinositol 3-kinase, Vps34, in phagocytosis, autophagy, and endocytosis in retinal pigmented epithelium · Feng He · 2025 · 9 citations · Cited by this paper

Source: OpenAlex (CC0)