Research map: Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling

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  1. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 · Hong Sun · 2021 · 10322 citations · Cited by this paper
  2. Callistephus A from Callistephus chinensis alleviates DSS-induced ulcerative colitis and gut–liver axis disruption by targeting the JAK2/STAT1 pathway and remodeling gut microbiota · 2026 · Related
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  13. Bile acids in glucose metabolism in health and disease · Hagit Shapiro · 2018 · 473 citations · Cited by this paper
  14. Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment · 2026 · Related
  15. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism · Xiaojiao Zheng · 2020 · 472 citations · Cited by this paper
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  17. The interactions between gut microbiota and bioactive ingredients of traditional Chinese medicines: A review · Xue Gong · 2020 · 183 citations · Cited by this paper
  18. Yishen Tongluo formula regulates apoptosis and autophagy in testicular spermatogenic cells of oligoasthenozoospermic rats via the AMPK/mTOR pathway · 2026 · Related
  19. A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage · Ting Li · 2024 · 146 citations · Cited by this paper
  20. Comprehensive multiscale characterization, in vivo antioxidant activity, and subacute toxicity assessment of pearl powder · 2026 · Related
  21. Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice · Lili Ding · 2021 · 115 citations · Cited by this paper
  22. Transport and biological activities of bile acids · Brittnee L. Zwicker · 2013 · 110 citations · Cited by this paper
  23. Chemoproteomic Profiling of Bile Acid Interacting Proteins · Shentian Zhuang · 2017 · 108 citations · Cited by this paper
  24. Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells · Zhigang Yang · 2011 · 101 citations · Cited by this paper
  25. Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration · Guodong Li · 2015 · 74 citations · Cited by this paper
  26. Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress · Meiqi Wang · 2023 · 70 citations · Cited by this paper
  27. Markers of metabolic health and gut microbiome diversity: findings from two population-based cohort studies · Sémi Zouiouich · 2021 · 67 citations · Cited by this paper
  28. Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition · Ling Gao · 2017 · 52 citations · Cited by this paper
  29. Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway · Yewei Jia · 2020 · 51 citations · Cited by this paper
  30. Novel active compounds and the anti-diabetic mechanism of mulberry leaves · Qiuyue Lv · 2022 · 47 citations · Cited by this paper
  31. Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism · Fengyuan Tian · 2022 · 43 citations · Cited by this paper
  32. Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid · Xiao‐xiao Zheng · 2023 · 39 citations · Cited by this paper
  33. Antitumor Effect of Morusin via G1 Arrest and Antiglycolysis by AMPK Activation in Hepatocellular Cancer · Ah Reum Cho · 2021 · 36 citations · Cited by this paper
  34. Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats · Gaurav Gupta · 2016 · 32 citations · Cited by this paper
  35. Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway · Yuqi Zhou · 2021 · 31 citations · Cited by this paper
  36. Flavonoids and the gut microbiome: a powerful duo for brain health · Soroush Taherkhani · 2024 · 30 citations · Cited by this paper
  37. Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed ofMorus alba,Yerba mate, andMagnolia officinalis · Mesfin Yimam · 2016 · 24 citations · Cited by this paper
  38. Antioxidant role of morusin and mulberrofuran B in ethanol extract of Morus alba roots · Bruna de Almeida Martins · 2020 · 19 citations · Cited by this paper
  39. Effects and Mechanistic Role of Mulberry Leaves in Treating Diabetes and its Complications · Yanjiao Zhang · 2023 · 14 citations · Cited by this paper

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