Research map: Mathematical modeling of T cell exhaustion in the tumor microenvironment

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  1. Molecular and cellular insights into T cell exhaustion · E. John Wherry · 2015 · 4756 citations · Cited by this paper
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  19. T Cell Exhaustion · Andrew Baessler · 2024 · 394 citations · Cited by this paper
  20. Overcoming TGFβ-mediated immune evasion in cancer · Daniele V. F. Tauriello · 2021 · 377 citations · Cited by this paper
  21. TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma · Xiaochen Wang · 2019 · 296 citations · Cited by this paper
  22. Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies · Jill A. Gallaher · 2018 · 296 citations · Cited by this paper
  23. Mathematical Modeling of Tumor Growth and Treatment · Heiko Enderling · 2014 · 208 citations · Cited by this paper
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  25. Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment · Kerri‐Ann Norton · 2019 · 189 citations · Cited by this paper
  26. A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition · Chang Gong · 2017 · 179 citations · Cited by this paper
  27. Boolean Network Model for Cancer Pathways: Predicting Carcinogenesis and Targeted Therapy Outcomes · Herman Fialho Fumiã · 2013 · 174 citations · Cited by this paper
  28. A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction · Helen A. Moore · 2004 · 161 citations · Cited by this paper
  29. Mechanisms of T-Cell Exhaustion in Pancreatic Cancer · Didem Saka · 2020 · 160 citations · Cited by this paper
  30. The current state and future of T-cell exhaustion research · Edward M. Jenkins · 2023 · 138 citations · Cited by this paper
  31. Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution · Ivana Božić · 2016 · 137 citations · Cited by this paper
  32. Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division · Michael W. Rudloff · 2023 · 137 citations · Cited by this paper
  33. Metabolic reprogramming in tumor immune microenvironment: Impact on immune cell function and therapeutic implications · Yuqiang Liu · 2024 · 134 citations · Cited by this paper
  34. Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy · Lawrence Peter Andrews · 2022 · 129 citations · Cited by this paper
  35. Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment · Jing Bo Wang · 2024 · 109 citations · Cited by this paper
  36. Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans · Can Liu · 2020 · 104 citations · Cited by this paper
  37. A hybrid multi-compartment model of granuloma formation and T cell priming in Tuberculosis · Simeone Marino · 2011 · 97 citations · Cited by this paper
  38. Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells · Nadia Bannoud · 2021 · 91 citations · Cited by this paper
  39. Stability and bifurcation analysis of delay induced tumor immune interaction model · Subhas Khajanchi · 2014 · 86 citations · Cited by this paper

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