Research map: Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species

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  1. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants · David R. Nelson · 2003 · 1052 citations · Cited by this paper
  2. In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs · Chizuka Sakai · 2026 · 1 citation · Related
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  11. Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression · Sevasti B. Koukouritaki · 2002 · 246 citations · Cited by this paper
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  13. Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog · Chuang Lu · 2001 · 205 citations · Cited by this paper
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  17. TRIMETHYLAMINURIA: THE FISH-ODOUR SYNDROME · James R. Humbert · 1970 · 166 citations · Cited by this paper
  18. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  19. Expression of CYP2A genes in human liver and extrahepatic tissues · Satu Koskela · 1999 · 155 citations · Cited by this paper
  20. Different Roles of Canine Cytochrome P450 2C and 3A Enzymes Involved in the Oxidative Metabolism of Phenobarbital, a Key Anticonvulsant for Dogs: Comparison With Human P450 Enzymes · 2026 · Related
  21. Differential Developmental and Tissue‐Specific Regulation of Expression of the Genes Encoding Three Members of the Flavin‐Containing Monooxygenase Family of Man, FMO1, FMO3 and FMO4 · Colin T. Dolphin · 1996 · 154 citations · Cited by this paper
  22. The Flavin-containing Monooxygenase 2 Gene (FMO2) of Humans, but Not of Other Primates, Encodes a Truncated, Nonfunctional Protein · Colin T. Dolphin · 1998 · 140 citations · Cited by this paper
  23. Mapping DNA structural variation in dogs · Weikang Chen · 2008 · 136 citations · Cited by this paper
  24. Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine · Jaana Hartiala · 2014 · 133 citations · Cited by this paper
  25. CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone · Yasuhiro Uno · 2006 · 120 citations · Cited by this paper
  26. Evidence for Polymorphism in the Canine Metabolism of the Cyclooxygenase 2 Inhibitor, Celecoxib · Susan K. Paulson · 1999 · 119 citations · Cited by this paper
  27. Cytochrome P450 Sex Differences in Minipigs and Conventional Pigs · Mette T. Skaanild · 1999 · 115 citations · Cited by this paper
  28. Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model · Emanuela Puccinelli · 2011 · 109 citations · Cited by this paper
  29. Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry · Brahim Achour · 2011 · 95 citations · Cited by this paper
  30. Canine Cytochrome P-450 Pharmacogenetics · Michael H. Court · 2013 · 93 citations · Cited by this paper
  31. Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1) · Colin T. Dolphin · 1991 · 91 citations · Cited by this paper
  32. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes · Yasuhiro Uno · 2016 · 81 citations · Cited by this paper
  33. Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARα in nonproliferating species · Yewon Cheon · 2005 · 77 citations · Cited by this paper
  34. SUBSTRATE SPECIFICITY AND KINETIC PROPERTIES OF SEVEN HETEROLOGOUSLY EXPRESSED DOG CYTOCHROMES P450 · Magang Shou · 2003 · 77 citations · Cited by this paper
  35. Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease · Ian Richard Phillips · 2019 · 72 citations · Cited by this paper
  36. The flavin-containing monooxygenase expressed in pig liver: primary sequence, distribution, and evidence for a single gene · Rodolfo Gasser · 1990 · 63 citations · Cited by this paper
  37. Expression and Characterization of Canine Cytochrome P450 2D15 · Fabienne Roussel · 1998 · 63 citations · Cited by this paper
  38. Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics · Marilyn N. Martinez · 2013 · 62 citations · Cited by this paper
  39. In Vivo and in Vitro Induction of Cytochrome P450 Enzymes in Beagle Dogs · Richard Graham · 2002 · 60 citations · Cited by this paper

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