Research map: Crosstalk Between Mitophagy and Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

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Papers in this map

  1. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents · Helmut Sies · 2020 · 5290 citations · Cited by this paper
  2. Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS–DLAT axis and promoting M2 macrophage polarization · 2026 · Related
  3. Otto Warburg's contributions to current concepts of cancer metabolism · Willem Hendrik Koppenol · 2011 · 3514 citations · Cited by this paper
  4. Cyclophilin D (CypD) promotes mitochondrial impairment, synaptic defects, cognitive loss, and tau pathology during aging · 2026 · Related
  5. Mitochondrial TCA cycle metabolites control physiology and disease · Inmaculada Martínez‐Reyes · 2020 · 2898 citations · Cited by this paper
  6. Myeloid HIF-1α couples glycolytic energy supply with NCF2-dependent oxidative killing to protect against Klebsiella pneumoniae pneumonia · 2026 · Related
  7. Oxidative Stress in Cancer · John David Hayes · 2020 · 2655 citations · Cited by this paper
  8. Inhibiting VDAC1 oligomerization attenuated cerebral ischemia-reperfusion injury by promoting mitophagy via reduced LONP1 interaction · 2026 · Related
  9. Autophagy and Metabolism · Joshua D. Rabinowitz · 2010 · 2011 citations · Cited by this paper
  10. Salvianolic acid B mitigates neuronal ferroptosis after intracerebral hemorrhage in rats through a Piezo1-associated AMPK–mTOR pathway · 2026 · Related
  11. Macrophages and Metabolism in the Tumor Microenvironment · Ilio Vitale · 2019 · 1933 citations · Cited by this paper
  12. Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress · 2026 · Related
  13. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? · Simran Singh Sabharwal · 2014 · 1656 citations · Cited by this paper
  14. GPX3 downregulation in alveolar macrophages amplifies IL-17–dependent redox–inflammation crosstalk in ARDS · 2026 · Related
  15. Ferroptosis at the intersection of lipid metabolism and cellular signaling · Deguang Liang · 2022 · 1367 citations · Cited by this paper
  16. VBIT-4 attenuates diabetes-associated cardiovascular mitochondrial dysfunction and ROS production in a mouse model of diabetes and hyperlipidemic cellular assays · 2026 · Related
  17. Mitochondria and Cancer · Wei‐Xing Zong · 2016 · 1336 citations · Cited by this paper
  18. Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy · 2026 · Related
  19. Reactive oxygen species and mitochondria: A nexus of cellular homeostasis · Joe Dan Dunn · 2015 · 1249 citations · Cited by this paper
  20. Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation · 2026 · Related
  21. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells · Lucas B. Sullivan · 2015 · 1231 citations · Cited by this paper
  22. Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling · Martin D. Brand · 2016 · 1076 citations · Cited by this paper
  23. The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways · Zhigao Wang · 2012 · 964 citations · Cited by this paper
  24. Lipid metabolism reprogramming and its potential targets in cancer · Chunming Cheng · 2018 · 877 citations · Cited by this paper
  25. How the Warburg effect supports aggressiveness and drug resistance of cancer cells? · Philippe Icard · 2018 · 686 citations · Cited by this paper
  26. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion · Yi-Ru Yu · 2020 · 602 citations · Cited by this paper
  27. Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy · Shari Pilon‐Thomas · 2016 · 600 citations · Cited by this paper
  28. Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells · Farhan Basit · 2017 · 587 citations · Cited by this paper
  29. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy · R. David Sentelle · 2012 · 545 citations · Cited by this paper
  30. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage · Hiroko P. Indo · 2006 · 534 citations · Cited by this paper
  31. ROS production by mitochondria: function or dysfunction? · Flávio Romero Palma · 2023 · 507 citations · Cited by this paper
  32. The role of PINK1–Parkin in mitochondrial quality control · Derek P. Narendra · 2024 · 501 citations · Cited by this paper
  33. Lactate and lactylation in cancer · Jie Chen · 2025 · 461 citations · Cited by this paper
  34. Receptor-mediated mitophagy in yeast and mammalian systems · Lei Liu · 2014 · 424 citations · Cited by this paper
  35. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells · Jessie Yanxiang Guo · 2016 · 389 citations · Cited by this paper
  36. The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics · Debasna Pritimanjari Panigrahi · 2019 · 388 citations · Cited by this paper
  37. The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks · Jie Li · 2023 · 376 citations · Cited by this paper
  38. SIRT5 regulation of ammonia-induced autophagy and mitophagy · Lucia Polletta · 2015 · 347 citations · Cited by this paper
  39. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis · Aparajita H. Chourasia · 2015 · 336 citations · Cited by this paper

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