Research map: Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy

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  1. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation · Qisheng Lin · 2019 · 639 citations · Cited by this paper
  2. Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy · 2026 · Related
  3. Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options · Di Liu · 2022 · 618 citations · Cited by this paper
  4. Interpretable Machine Learning in Heavy Metal-Associated Cardiovascular and Metabolic Disease: A Review of Current Methodologies, Toxicological Insights, and Clinical Implications · 2026 · Related
  5. Mitochondria in Health and Disease · Sarah Jane Annesley · 2019 · 556 citations · Cited by this paper
  6. Drug-Induced Noninfectious Myocarditis/Pericarditis: A Real-World Pharmacovigilance Study Using the FAERS Database · 2026 · Related
  7. Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy · Hao Zhou · 2018 · 419 citations · Cited by this paper
  8. Tnxb Alleviates Myocardial Ischemia-Reperfusion Injury Through Facilitating Akt-Dependent Endothelial Cell Survival and Angiogenesis in Mice · 2026 · Related
  9. RNA modification: mechanisms and therapeutic targets · Lei Qiu · 2023 · 174 citations · Cited by this paper
  10. GLI1 Promotes Hypoxia Induced Pyroptosis of PASMCs and Aggravates Pulmonary Arterial Hypertension in Rats by Upregulating HDAC1 Expression · 2026 · Related
  11. New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation · Yukun Li · 2024 · 166 citations · Cited by this paper
  12. E-cigarette Aerosol Containing Nicotine Increases Aortic Stiffness in Young Mice · 2026 · Related
  13. USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury · Jian Sun · 2021 · 141 citations · Cited by this paper
  14. Microplastics and Nanoplastics in Cardiovascular Disease: An Emerging Cardiovascular Risk Factor · 2026 · Related
  15. Current Status of Septic Cardiomyopathy: Basic Science and Clinical Progress · Huan Lin · 2020 · 136 citations · Cited by this paper
  16. Pioglitazone Mitigates Arsenic-Induced Cardiotoxicity via Lipid Metabolism: Network Pharmacology and Molecular Docking Approach · 2026 · Related
  17. Structures and mechanisms of tRNA methylation by METTL1–WDR4 · Víctor Manuel Ruiz-Arroyo · 2023 · 132 citations · Cited by this paper
  18. Role of l-Arginine and Tetrahydrobiopterin in Attenuation of Vascular Ang1-8 Reactivity via Endothelial PI3K/AKT/eNOS Signaling Pathways in HgCl2-Induced Vascular Dysfunction. An Ex-Vivo Study · 2026 · Related
  19. Nrf2 Deficiency Exacerbated CLP-Induced Pulmonary Injury and Inflammation through Autophagy- and NF-κB/PPARγ-Mediated Macrophage Polarization · Jing Luo · 2022 · 108 citations · Cited by this paper
  20. SETD2 Improves Endothelial Function and Angiogenesis in Diabetic Hindlimb Ischemia Via Activating ANGPT2-PI3K/AKT Pathway · 2026 · Related
  21. NOX4 is a potential therapeutic target in septic acute kidney injury by inhibiting mitochondrial dysfunction and inflammation · Jiameng Li · 2023 · 103 citations · Cited by this paper
  22. Novel roles of METTL1/WDR4 in tumor via m7G methylation · Wenli Cheng · 2022 · 101 citations · Cited by this paper
  23. TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury · Hao Zhou · 2023 · 101 citations · Cited by this paper
  24. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy · Tatsuki Kuroshima · 2024 · 68 citations · Cited by this paper
  25. PTEN induced putative kinase 1 (PINK1) alleviates angiotensin II-induced cardiac injury by ameliorating mitochondrial dysfunction · Wenjun Xiong · 2018 · 67 citations · Cited by this paper
  26. Biological roles of RNA m7G modification and its implications in cancer · Xin Zhang · 2023 · 67 citations · Cited by this paper
  27. Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review) · Jiayu Song · 2023 · 63 citations · Cited by this paper
  28. Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function · Xin-xin Zhu · 2023 · 59 citations · Cited by this paper
  29. TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA · Xinzhe Chen · 2023 · 52 citations · Cited by this paper
  30. The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4 · Shuting Yu · 2024 · 42 citations · Cited by this paper
  31. Fibroblast-specific knockout of METTL1 attenuates myocardial infarction-induced cardiac fibrosis · Liang Wang · 2023 · 41 citations · Cited by this paper
  32. Mst1 deletion reduces septic cardiomyopathy via activating Parkin‐related mitophagy · Xiuling Shang · 2019 · 39 citations · Cited by this paper
  33. lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation · Xiaowei Niu · 2024 · 39 citations · Cited by this paper
  34. m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes · Dianbo Long · 2024 · 32 citations · Cited by this paper
  35. N7-methylguanosine modification: from regulatory roles to therapeutic implications in cancer. · Mengyuan Cai · 2023 · 28 citations · Cited by this paper
  36. Regulation of mitochondrial autophagy by lncRNA MALAT1 in sepsis-induced myocardial injury · Guangqing Huang · 2024 · 22 citations · Cited by this paper
  37. Po-Ge-Jiu-Xin decoction alleviate sepsis-induced cardiomyopathy via regulating phosphatase and tensin homolog-induced putative kinase 1 /parkin-mediated mitophagy · Zheng Wang · 2024 · 21 citations · Cited by this paper
  38. Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy · Yan Cui · 2024 · 20 citations · Cited by this paper
  39. Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy · Hua Ye · 2024 · 18 citations · Cited by this paper

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