Research map: Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer’s disease

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  1. Neuropathological stageing of Alzheimer-related changes · Heiko Braak · 1991 · 16633 citations · Cited by this paper
  2. A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease · 2026 · Related
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  15. Amyloid Precursor Protein Trafficking, Processing, and Function · Gopal Thinakaran · 2008 · 1147 citations · Cited by this paper
  16. CTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC · 2026 · Related
  17. Molecular pathways to neurodegeneration · Ella Bossy‐Wetzel · 2004 · 741 citations · Cited by this paper
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  19. Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies · Cosmin Lazar · 2016 · 585 citations · Cited by this paper
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  21. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease · Yosef Koronyo · 2017 · 538 citations · Cited by this paper
  22. Synaptic degeneration in Alzheimer disease · Makis Tzioras · 2022 · 518 citations · Cited by this paper
  23. 2025 Alzheimer's disease facts and figures · 2025 · 459 citations · Cited by this paper
  24. Melanopsin retinal ganglion cell loss in A lzheimer disease · Chiara La Morgia · 2015 · 405 citations · Cited by this paper
  25. CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data · CZI Cell Science Program · 2024 · 384 citations · Cited by this paper
  26. Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina · Janet C. Blanks · 1996 · 338 citations · Cited by this paper
  27. Retinal ganglion cells in Alzheimer's disease and aging · Christine A. Curcio · 1993 · 309 citations · Cited by this paper
  28. Retinal thickness in Alzheimer's disease: A systematic review and meta‐analysis · Jurre den Haan · 2017 · 259 citations · Cited by this paper
  29. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study · G. Lace · 2009 · 256 citations · Cited by this paper
  30. Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia · Ünal Mutlu · 2018 · 244 citations · Cited by this paper
  31. Amyloid-beta and phosphorylated tau in post-mortem Alzheimer’s disease retinas · Jurre den Haan · 2018 · 243 citations · Cited by this paper
  32. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles · Betty Marije Tijms · 2024 · 212 citations · Cited by this paper
  33. Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression · Yu Yamazaki · 2019 · 205 citations · Cited by this paper
  34. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease · Erik C. B. Johnson · 2023 · 189 citations · Cited by this paper
  35. Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease · Sunil Shankar Adav · 2019 · 184 citations · Cited by this paper
  36. Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease · David Hondius · 2016 · 174 citations · Cited by this paper
  37. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis · Alfonso Grimaldi · 2019 · 170 citations · Cited by this paper
  38. Retinal pathological features and proteome signatures of Alzheimer’s disease · Yosef Koronyo · 2023 · 166 citations · Cited by this paper
  39. Gyrate atrophy of the choroid and retina associated with hyperornithinaemia. · Kirsti K. Takki · 1974 · 147 citations · Cited by this paper

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