Research map: The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells

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  1. Widespread Occurrence and Transport of p-Phenylenediamines and Their Quinones in Sediments across Urban Rivers, Estuaries, Coasts, and Deep-Sea Regions · Lixi Zeng · 2023 · 244 citations · Cited by this paper
  2. Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression · 2026 · Related
  3. First Report on the Occurrence of N -(1,3-Dimethylbutyl)- N ′-phenyl- p -phenylenediamine (6PPD) and 6PPD-Quinone as Pervasive Pollutants in Human Urine from South China · Bibai Du · 2022 · 240 citations · Cited by this paper
  4. Alternariol, a mycotoxin, induces oxidative stress, inflammation, and apoptosis in human astrocytes: Protective effects of eicosapentaenoic acid · 2026 · Related
  5. NCM460, a normal human colon mucosal epithelial cell line · Mary Pat Moyer · 1996 · 238 citations · Cited by this paper
  6. Integrative network toxicology identifies SLC5A2 as a key mediator of tetrasodium pyrophosphate-induced renal fibrosis · 2026 · Related
  7. Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice · Liya Fang · 2023 · 221 citations · Cited by this paper
  8. RIFM fragrance ingredient safety assessment, 3,5,5-trimethylcyclohexanol, CAS Registry Number 116-02-9 · 2026 · Related
  9. Transformation Products of Tire Rubber Antioxidant 6PPD in Heterogeneous Gas-Phase Ozonation: Identification and Environmental Occurrence · Haoqi Nina Zhao · 2023 · 185 citations · Cited by this paper
  10. BPAF-induced inflammatory response via estrogen signaling: insights from in vivo and in vitro evidence · 2026 · Related
  11. Uptake, Metabolism , and Accumulation of Tire Wear Particle-Derived Compounds in Lettuce · Stephanie Castan · 2022 · 173 citations · Cited by this paper
  12. Update to RIFM fragrance ingredient safety assessment, 2-propanol, 1,1′,1′,1'-(1,2-ethanediyldinitrilo)tetrakis-, CAS Registry Number 102-60-3 · 2026 · Related
  13. 6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish · Shuyun Zhang · 2023 · 168 citations · Cited by this paper
  14. Redox-dependent cytoprotection by zerumbone via Nrf2–Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells · 2026 · Related
  15. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans · Xin Jun Hua · 2022 · 125 citations · Cited by this paper
  16. Microplastics and mammary carcinogenesis: A review of in vitro and in vivo experimental evidence · 2026 · Related
  17. Solar-light-activated periodate for degradation and detoxification of highly toxic 6PPD-quinone at environmental levels · Long Chen · 2024 · 125 citations · Cited by this paper
  18. Insights into natural polysaccharides in alleviating drug-induced liver injury: Protective mechanisms and recent advances · 2026 · Related
  19. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding · Jiacheng Fang · 2023 · 123 citations · Cited by this paper
  20. High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage · Yunjia Lai · 2024 · 121 citations · Cited by this paper
  21. Occurrence and Fate of Substituted p -Phenylenediamine-Derived Quinones in Hong Kong Wastewater Treatment Plants · Guodong Cao · 2023 · 120 citations · Cited by this paper
  22. Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice · Kezhen Yao · 2024 · 100 citations · Cited by this paper
  23. Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis · Junhui Yu · 2020 · 92 citations · Cited by this paper
  24. Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout · Xiao-Liang Liao · 2023 · 86 citations · Cited by this paper
  25. Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans · Xin Hua · 2024 · 75 citations · Cited by this paper
  26. Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation · Yan Yang · 2024 · 68 citations · Cited by this paper
  27. Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics · Wenmiao He · 2024 · 68 citations · Cited by this paper
  28. Tissue Accumulation and Biotransformation of 6PPD-Quinone in Adult Zebrafish and Its Effects on the Intestinal Microbial Community · Xiao-Liang Liao · 2024 · 68 citations · Cited by this paper
  29. Stable isotope-assisted mass spectrometry reveals in vivo distribution, metabolism, and excretion of tire rubber-derived 6PPD-quinone in mice · Jing Zhang · 2023 · 64 citations · Cited by this paper
  30. Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice · Bo Li · 2025 · 63 citations · Cited by this paper
  31. Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration · Cynthia R. Barrera · 2018 · 60 citations · Cited by this paper
  32. Exposure to 6-PPD quinone enhances lipid accumulation through activating metabolic sensors of SBP-1 and MDT-15 in Caenorhabditis elegans · Yuxing Wang · 2023 · 60 citations · Cited by this paper
  33. Comparison of intestinal toxicity in enhancing intestinal permeability and in causing ROS production of six PPD quinones in Caenorhabditis elegans · Yuxing Wang · 2024 · 49 citations · Cited by this paper
  34. Tire Rubber Antioxidant 6PPD and 6PPD-quinone Disrupt the Energy Supply and Lipid Metabolism of Earthworms · Ruiying Shi · 2025 · 47 citations · Cited by this paper
  35. Cellular Functional, Protective or Damaging Responses Associated with Different Redox Imbalance Intensities: A Comprehensive Review · Andrea del Campo · 2022 · 46 citations · Cited by this paper
  36. Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans · Yuxing Wang · 2024 · 46 citations · Cited by this paper
  37. 6-PPD quinone at environmentally relevant concentrations induced damage on longevity in C. elegans: Mechanistic insight from inhibition in mitochondrial UPR response · Xin Hua · 2024 · 44 citations · Cited by this paper
  38. 6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage · Baoqiang Fu · 2024 · 42 citations · Cited by this paper
  39. Navigating the environmental dynamics, toxicity to aquatic organisms and human associated risks of an emerging tire wear contaminant 6PPD-quinone · Syed Shabi Ul Hassan Kazmi · 2024 · 42 citations · Cited by this paper

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