Research map: Complexities in the Diagnostic Evaluation and Treatment of Infant Hemophagocytic Lymphohistiocytosis

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Papers in this map

  1. HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis · Jan‐Inge Henter · 2006 · 5456 citations · Cited by this paper
  2. Concomitant Clonal CBFB::MYH11 and PDGFRB Fusions in a Case of De Novo Acute Myeloid Leukemia · 2026 · Related
  3. Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome · Laurence Fardet · 2014 · 1506 citations · Cited by this paper
  4. The Utility of IgG4/IgG Ratio in the Diagnosis of Multicentric Castleman Disease: A Case Report of HHV8+ Castleman Disease in a Patient with Classical Hodgkin’s Lymphoma · 2026 · Related
  5. Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis · Susan E. Stepp · 1999 · 1245 citations · Cited by this paper
  6. Paraneoplastic Neuro-Ophthalmologic Symptoms as Initial Manifestation of Hodgkin Lymphoma · 2026 · Related
  7. Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa · Timothy M. Uyeki · 2018 · 808 citations · Cited by this paper
  8. Advances in Gene Therapy for Inherited Haemoglobinopathies · 2025 · Related
  9. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome · Scott Canna · 2014 · 757 citations · Cited by this paper
  10. Inherited Platelet Disorders During Pregnancy and Delivery: Overview of Management Strategies and Emerging Therapeutic Considerations · 2026 · Related
  11. Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study · Elisabet Bergsten · 2017 · 683 citations · Cited by this paper
  12. Primary Bone Lymphoma of the Jaw Masquerading as Infection and Delaying Treatment · 2026 · Related
  13. Infections associated with haemophagocytic syndrome · Nadine Rouphael · 2007 · 598 citations · Cited by this paper
  14. Clinical Experience with Emicizumab and Rituximab as First-Line Treatment in a Case Series of Acquired Hemophilia A · 2026 · Related
  15. Pediatric hemophagocytic lymphohistiocytosis · Scott Canna · 2020 · 503 citations · Cited by this paper
  16. Quality of Life in CAR-T Cell Therapy · 2026 · Related
  17. Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO) · Michael B. Jordan · 2019 · 433 citations · Cited by this paper
  18. Asciminib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Case Series and Review of Emerging Evidence · 2026 · Related
  19. Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis · Claudia Bracaglia · 2016 · 296 citations · Cited by this paper
  20. A Scoring System for the Assessment of Quality of Care in the Management of Transfusion Dependent Thalassemia · 2026 · Related
  21. A consensus review on malignancy‐associated hemophagocytic lymphohistiocytosis in adults · Naval Guastad Daver · 2017 · 266 citations · Cited by this paper
  22. A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function · Michael T. Lam · 2019 · 215 citations · Cited by this paper
  23. Hemophagocytic Lymphohistiocytosis · Jan‐Inge Henter · 2025 · 210 citations · Cited by this paper
  24. Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza · Grant S. Schulert · 2015 · 175 citations · Cited by this paper
  25. Physiologically based serum ferritin thresholds for iron deficiency in children and non-pregnant women: a US National Health and Nutrition Examination Surveys (NHANES) serial cross-sectional study · Zuguo Mei · 2021 · 164 citations · Cited by this paper
  26. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ · Karen Put · 2015 · 147 citations · Cited by this paper
  27. Haemophagocytic lymphohistiocytosis and Epstein–Barr virus: a complex relationship with diverse origins, expression and outcomes · Nader Kim El‐Mallawany · 2021 · 136 citations · Cited by this paper
  28. IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome · Shima Yasin · 2019 · 117 citations · Cited by this paper
  29. Clinical Characteristics and Treatment Outcomes of Autoimmune‐Associated Hemophagocytic Syndrome in Adults · Shunichi Kumakura · 2014 · 114 citations · Cited by this paper
  30. Hemophagocytic Lymphohistiocytosis: Clinical Presentations and Diagnosis · Kimberly Risma · 2018 · 112 citations · Cited by this paper
  31. Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis · Yuqing Zhou · 2020 · 111 citations · Cited by this paper
  32. Pediatric CNS-isolated hemophagocytic lymphohistiocytosis · Leslie A. Benson · 2019 · 98 citations · Cited by this paper
  33. A systematic review of malignancy-associated hemophagocytic lymphohistiocytosis that needs more attentions · Hongluan Wang · 2017 · 97 citations · Cited by this paper
  34. Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses · Andreas Westphal · 2016 · 66 citations · Cited by this paper
  35. Hemophagocytic lymphohistiocytosis: A disorder of T cell activation, immune regulation, and distinctive immunopathology · Michael B. Jordan · 2023 · 52 citations · Cited by this paper
  36. Haemophagocytic lymphohisticytosis—an underrecognized hyperinflammatory syndrome · Matthew Hutchinson · 2019 · 46 citations · Cited by this paper
  37. Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) · Emely L. Verweyen · 2021 · 45 citations · Cited by this paper
  38. Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus · Annemarie Steiner · 2021 · 37 citations · Cited by this paper
  39. Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression · Emma E. Hornick · 2019 · 28 citations · Cited by this paper

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