Research map: Toward a CKLM framework for integrated clinical trial design
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Papers in this map
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
· Zobair M. Younossi · 2023 · 3310 citations · Cited by this paper
Post-transplant CKLM: extending integrated clinical trial design to solid organ transplant recipients
· Alessandro Mattina · 2026 · Cites this paper
A patient-driven agenda for liver cirrhosis research
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A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association
· Chiadi E. Ndumele · 2023 · 1330 citations · Cited by this paper
International consensus on intestinal epithelial barrier assessment and therapeutic effects in inflammatory bowel diseases clinical trials
· 2026 · Related
MASLD: a systemic metabolic disorder with cardiovascular and malignant complications
· Giovanni Targher · 2024 · 882 citations · Cited by this paper
Large language models for detecting colorectal polyps in endoscopic images—further research is required
· 2026 · Related
Metabolic dysfunction-associated steatotic liver disease in adults
· Daniel Q. Huang · 2025 · 286 citations · Cited by this paper
USP20 promotes CD8 + T cell exhaustion and impairs KRAS G12D inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer
· 2026 · Related
The role of hepatokines in NAFLD
· Norbert Stefan · 2023 · 285 citations · Cited by this paper
Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification
· 2026 · Related
Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials
· Ellen M. Apperloo · 2024 · 156 citations · Cited by this paper
Cancer neuroscience in cholangiocarcinoma: from perineural invasion to neuroimmune control
· 2026 · Related
Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin
· Wei Xie · 2024 · 55 citations · Cited by this paper
Cryptogenic steatotic liver disease: a lean phenotype associated with increased liver-related mortality
· 2026 · Related
2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
· Chiadi E. Ndumele · 2026 · 35 citations · Cited by this paper
Safety and efficacy of extended surveillance intervals following colorectal endoscopic submucosal dissection: an international multicentre study
· 2026 · Related
MASLD and MASH at the crossroads of hepatology trials and cardiorenal metabolic trials
· Faiez M. Zannad · 2024 · 32 citations · Cited by this paper
Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease
· Luis Antonio Díaz · 2025 · 26 citations · Cited by this paper
Pharmacotherapy for metabolic dysfunction-associated steatohepatitis: heart–liver co-management
· Xiaodong Zhou · 2026 · 26 citations · Cited by this paper
MASLD, MASH, and the CKM Spectrum
· Faïez Zannad · 2026 · 25 citations · Cited by this paper
Cardiovascular–kidney–metabolic syndrome and MASLD: integrating medical perspectives
· Xiaodong Zhou · 2025 · 23 citations · Cited by this paper
Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities
· Xiao-Dong Zhou · 2025 · 22 citations · Cited by this paper
MASLD as a systemic metabolic disease: expanding the scope of cardiovascular-kidney-metabolic (CKM) syndrome
· Xiaodong Zhou · 2026 · 15 citations · Cited by this paper
Diagnostic innovation and models of care to improve fibrosis detection and risk stratification in steatotic liver disease
· Nicola Riccardo Pugliese · 2026 · 3 citations · Cited by this paper
Metabolic Liver Disease Beyond the Liver
· Amalia Gastaldelli · 2026 · 1 citation · Cited by this paper
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