Research map: Prevention of appearance of severe Huntington's disease symptoms in the R6/1 mouse model by early administration of 4′,5,7-trihydroxyisoflavone

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  1. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice · Laura Mangiarini · 1996 · 3117 citations · Cited by this paper
  2. Multimodal MRI integrating anti-motion multi-parametric mappings for investigating subcortical nuclei microstructural alterations in Huntington's disease · 2026 · Related
  3. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease · Brinda Ravikumar · 2004 · 2354 citations · Cited by this paper
  4. Effects of computerized cognitive training on functional activity and connectivity in Huntington's disease: A pilot study · 2025 · Related
  5. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy · Brinda Ravikumar · 2002 · 1114 citations · Cited by this paper
  6. Mapping the landscape of caregiver burden in Huntington's Disease: Current evidence and future directions · 2025 · Related
  7. Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease · Robert E. Handsaker · 2025 · 205 citations · Cited by this paper
  8. Phase-targeted auditory stimulation enhances slow-wave activity during sleep in Huntington's disease: A pilot crossover study · 2026 · Related
  9. Evaluation of Blood–Brain Barrier Permeability of Polyphenols, Anthocyanins, and Their Metabolites · Rena Shimazu · 2021 · 138 citations · Cited by this paper
  10. Understanding the relationship between patient-reported outcome measures, clinician-rated assessments, and performance-based measures (cognitive tests and device-based estimates) of symptoms and functioning in people with Huntington's disease · 2025 · Related
  11. Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases · Karolina Pierzynowska · 2018 · 88 citations · Cited by this paper
  12. Contribution of neuroepigenetics to HD – developmental and aging-related signatures · 2026 · Related
  13. Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan · Qihang Hou · 2023 · 87 citations · Cited by this paper
  14. Dysregulated astrocyte cholesterol synthesis in Huntington's disease: A potential intersection with other cellular dysfunctions · 2025 · Related
  15. Huntington disease: Advances in the understanding of its mechanisms · Emilia Mabel Gatto · 2020 · 81 citations · Cited by this paper
  16. Insights into neurodevelopmental features of Huntington's disease from stem cell-derived models including organoids · 2025 · Related
  17. High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system · Katherine H. Kim · 2013 · 76 citations · Cited by this paper
  18. Understanding Huntington’s Disease: Epidemiology, Mechanisms, and Modeling Approaches · 2026 · Related
  19. Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis · Rachael I. Scahill · 2025 · 72 citations · Cited by this paper
  20. Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model · Karolina Pierzynowska · 2018 · 63 citations · Cited by this paper
  21. Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia · Akira M Sekikawa · 2022 · 63 citations · Cited by this paper
  22. Soy isoflavones protects against cognitive deficits induced by chronic sleep deprivation via alleviating oxidative stress and suppressing neuroinflammation · Cong Lü · 2022 · 52 citations · Cited by this paper
  23. Daidzein and Genistein: Natural Phytoestrogens with Potential Applications in Hormone Replacement Therapy · Aekkhaluck Intharuksa · 2025 · 47 citations · Cited by this paper
  24. CAG repeat RNA as an auxiliary toxic agent in polyglutamine disorders · Marzena Wojciechowska · 2011 · 45 citations · Cited by this paper
  25. Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients · Karolina Pierzynowska · 2019 · 35 citations · Cited by this paper
  26. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models · Aurélie de Rus Jacquet · 2021 · 32 citations · Cited by this paper
  27. Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation · Karolina Pierzynowska · 2023 · 31 citations · Cited by this paper
  28. Autophagy system as a potential therapeutic target for neurodegenerative diseases · Mengying Cui · 2022 · 28 citations · Cited by this paper
  29. Huntington disease: somatic expansion, pathobiology and therapeutics · Jasmine Donaldson · 2025 · 25 citations · Cited by this paper
  30. Cell type- and region-specific enhancement of adult hippocampal neurogenesis by daidzein in middle-aged female mice · Jun Yamada · 2016 · 22 citations · Cited by this paper
  31. Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation? · Simone Engelender · 2022 · 21 citations · Cited by this paper
  32. Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease · Magdalena Podlacha · 2022 · 18 citations · Cited by this paper
  33. Genistein ameliorates glucose-induced β-amyloid toxicity, oxidative stress, and aging in the C. elegans model of Alzheimer's disease · Jingwen Wang · 2025 · 10 citations · Cited by this paper
  34. Loss of the Sexually Dimorphic Neuro-Inflammatory Response in a Transgenic Mouse Model of Huntington’s Disease · Thibault Renoir · 2015 · 8 citations · Cited by this paper
  35. Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus · Consuelo Borrás · 2021 · 7 citations · Cited by this paper
  36. The microbiota-gut-brain axis in Huntington’s disease: Evidence, mechanisms and therapeutic opportunities · Yuxiu Gu · 2026 · 6 citations · Cited by this paper
  37. Neuroinflammatory control of metabolism in huntington’s disease: central role of P2 × 7 receptor mediated redox lipid/epigenetic crosstalk · Vandana Bhatia · 2026 · 5 citations · Cited by this paper
  38. Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity · Maciej Kwieciński · 2026 · 4 citations · Cited by this paper
  39. Review article: Improving mitochondrial function: Current therapeutic perspectives in neurodegenerative diseases · Julia Brechtel · 2026 · 4 citations · Cited by this paper

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