Research map: Beyond Affinity: AI-Supported Developability Assessment and Multi-Objective Optimization in Antibody Development

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Papers in this map

  1. Evolutionary-scale prediction of atomic-level protein structure with a language model · Zeming Lin · 2023 · 5594 citations · Cited by this paper
  2. The evolving landscape of enzymatic technologies for precision synthesis of antibody–drug conjugates · 2026 · Related
  3. De novo design of protein structure and function with RFdiffusion · Joseph L. Watson · 2023 · 2270 citations · Cited by this paper
  4. Mass photometry reveals stoichiometry and binding dynamics of bispecific tetravalent anti-VEGF-PD-1 antibody ivonescimab · 2026 · Related
  5. ProteinBERT: a universal deep-learning model of protein sequence and function · Nadav Brandes · 2022 · 1068 citations · Cited by this paper
  6. Anti-ANGPTL3 antibody and IL-22 fusion protein mitigate nephrotic syndrome via mitochondrial protection, anti-apoptosis, and autophagy suppression · 2026 · Related
  7. SAbDab: the structural antibody database · James B. Dunbar · 2013 · 763 citations · Cited by this paper
  8. Delivery devices and container closure systems for co-formulated and co-administered biologics · 2026 · Related
  9. SOLpro: accurate sequence-based prediction of protein solubility · Christophe N. Magnan · 2009 · 709 citations · Cited by this paper
  10. Integrative and Emerging Models in Antibody Research: A Comprehensive Review · 2025 · Related
  11. Biophysical properties of the clinical-stage antibody landscape · Tushar S. Jain · 2017 · 661 citations · Cited by this paper
  12. ASD: antigen-specific antibody database · 2026 · Related
  13. IEDB-AR: immune epitope database—analysis resource in 2019 · Sandeep Kumar Dhanda · 2019 · 455 citations · Cited by this paper
  14. Energy-based generative models for monoclonal antibodies · 2025 · Related
  15. CoV-AbDab: the coronavirus antibody database · Matthew I. J. Raybould · 2020 · 439 citations · Cited by this paper
  16. Structure and function of therapeutic antibodies approved by the US FDA in 2024 · 2025 · Related
  17. Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins · Liu Liming · 2017 · 399 citations · Cited by this paper
  18. Prediction of antibody non-specificity using protein language models and biophysical parameters · 2026 · Related
  19. Five computational developability guidelines for therapeutic antibody profiling · Matthew I. J. Raybould · 2019 · 389 citations · Cited by this paper
  20. A high-throughput platform for biophysical antibody developability assessment to enable AI/ML model training · 2025 · Related
  21. Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences · Tobias Hegelund Olsen · 2021 · 366 citations · Cited by this paper
  22. ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins · Brennan Abanades · 2023 · 330 citations · Cited by this paper
  23. The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies · Anna Vaisman‐Mentesh · 2020 · 293 citations · Cited by this paper
  24. SaProt: Protein Language Modeling with Structure-aware Vocabulary · Jin Su · 2023 · 252 citations · Cited by this paper
  25. Predicting Antibody Developability Profiles Through Early Stage Discovery Screening · Marc Andre Bailly · 2020 · 235 citations · Cited by this paper
  26. Thera-SAbDab: the Therapeutic Structural Antibody Database · Matthew I. J. Raybould · 2019 · 224 citations · Cited by this paper
  27. Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies · Mimmi L. E. Lundahl · 2021 · 203 citations · Cited by this paper
  28. BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning · David Příhoda · 2022 · 201 citations · Cited by this paper
  29. Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years · Elena Alexander · 2024 · 193 citations · Cited by this paper
  30. Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics · Jasmine P. Davda · 2019 · 179 citations · Cited by this paper
  31. Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility · Lilia A. Rabia · 2018 · 165 citations · Cited by this paper
  32. ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation · Brennan Abanades · 2022 · 163 citations · Cited by this paper
  33. Antibodypedia, a Portal for Sharing Antibody and Antigen Validation Data · Erik Björling · 2008 · 153 citations · Cited by this paper
  34. Computational tool for the early screening of monoclonal antibodies for their viscosities · Neeraj J. Agrawal · 2015 · 138 citations · Cited by this paper
  35. Development of therapeutic antibodies for the treatment of diseases · Zeng Wang · 2022 · 136 citations · Cited by this paper
  36. Humanization of antibodies using a machine learning approach on large-scale repertoire data · Claire Marks · 2021 · 134 citations · Cited by this paper
  37. PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine · Reda Rawi · 2017 · 120 citations · Cited by this paper
  38. Aggregation risk prediction for antibodies and its application to biotherapeutic development · Olga Obrezanova · 2015 · 112 citations · Cited by this paper
  39. Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics · Pin‐Kuang Lai · 2022 · 108 citations · Cited by this paper

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