Research map: Targeting chitinase-3-like protein-1 in pancolitis by a drug-repurposing approach

Back to the article

Papers in this map

  1. Drug repurposing: progress, challenges and recommendations · Sudeep P. Pushpakom · 2018 · 4872 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
  3. Ulcerative colitis · Catherine Le Berre · 2023 · 1617 citations · Cited by this paper
  4. BiP-engaging xanthones from the mangosteen (Garcinia mangostana) induce androgen receptor degradation in prostate cancer cells · 2026 · Related
  5. S100A8/A9 in Inflammation · Siwen Wang · 2018 · 1523 citations · Cited by this paper
  6. Advanced therapy medicinal products for local treatment using new delivery methods · 2026 · Related
  7. Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury · Chun Geun Lee · 2011 · 946 citations · Cited by this paper
  8. Repurposing antiviral drugs targeting RNA viruses: A focus on the fusion protein of human metapneumovirus · 2026 · Related
  9. Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis · Michael P. Curry · 2015 · 813 citations · Cited by this paper
  10. CerS2/ceramide C24:1/ROCK2 signaling-mediated angiogenesis protects against ischemic brain injury in mice · 2026 · Related
  11. Ulcerative Colitis in Adults · Beatriz Gros · 2023 · 726 citations · Cited by this paper
  12. Core genes drive treatment resistance in triple-negative breast cancer: characteristics, mechanisms, intervention strategies · 2026 · Related
  13. Chitinase-3 like-protein-1 function and its role in diseases · Ting Zhao · 2020 · 582 citations · Cited by this paper
  14. HDAC1-mediated PKM2 delactylation modification regulates CIRP-induced angiogenesis in rheumatoid arthritis · 2026 · Related
  15. Chronic Inflammation in Cancer Development · Gabriele Multhoff · 2012 · 581 citations · Cited by this paper
  16. Orforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling · 2026 · Related
  17. Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease · Pia Munkholm · 2003 · 568 citations · Cited by this paper
  18. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  19. IL-1β and the Intestinal Epithelial Tight Junction Barrier · Lauren W. Kaminsky · 2021 · 436 citations · Cited by this paper
  20. Quercetin induces ferroptosis in ovarian cancer by suppressing the NRF2/HO‑1/GPX4 axis and increasing the efficacy of cisplatin · 2026 · Related
  21. Chronic ulcerative colitis and colorectal cancer · Gerhard Rogler · 2013 · 413 citations · Cited by this paper
  22. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes · Yangyang R. Yu · 2017 · 411 citations · Cited by this paper
  23. Multifunctional intracellular matrix metalloproteinases: implications in disease · Wesam Bassiouni · 2021 · 385 citations · Cited by this paper
  24. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes · Evemie Schutyser · 2005 · 273 citations · Cited by this paper
  25. CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease · Stephen I. Rennard · 2015 · 265 citations · Cited by this paper
  26. Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer · M Kawada · 2011 · 244 citations · Cited by this paper
  27. Crystal Structure and Carbohydrate-binding Properties of the Human Cartilage Glycoprotein-39 · Fabrizia Fusetti · 2003 · 242 citations · Cited by this paper
  28. A bibliometric review of drug repurposing · Nancy Baker · 2018 · 214 citations · Cited by this paper
  29. Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning · Onat Kadioglu · 2021 · 178 citations · Cited by this paper
  30. Vina-Carb: Improving Glycosidic Angles during Carbohydrate Docking · Anita K. Nivedha · 2016 · 157 citations · Cited by this paper
  31. Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases · In Jun Yeo · 2019 · 148 citations · Cited by this paper
  32. The expression and role of CXC chemokines in colorectal cancer · Hannelien Verbeke · 2011 · 143 citations · Cited by this paper
  33. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice · Allisson Freire Bento · 2008 · 140 citations · Cited by this paper
  34. Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling · Shunfeng Hu · 2021 · 137 citations · Cited by this paper
  35. Chitinase 3-Like-1 Expression in Colonic Epithelial Cells as a Potentially Novel Marker for Colitis-Associated Neoplasia · Chun‐Chuan Chen · 2011 · 110 citations · Cited by this paper
  36. Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer · Ji Eun Yu · 2024 · 108 citations · Cited by this paper
  37. A comprehensive network and pathway analysis of candidate genes in major depressive disorder · Peilin Jia · 2011 · 104 citations · Cited by this paper
  38. DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid · Tammie S. MacFie · 2014 · 102 citations · Cited by this paper
  39. Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9 · Daren Low · 2015 · 97 citations · Cited by this paper

Source: OpenAlex (CC0)