Research map: Pharmacological Switching in Minor Phytocannabinoids: A Mechanistic Framework for Compound–Indication Matching and Precision Neurotherapeutic Development

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  1. Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor · William A. Devane · 1992 · 5667 citations · Cited by this paper
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  5. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors · Raphael Mechoulam · 1995 · 2926 citations · Cited by this paper
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  13. An Introduction to the Endogenous Cannabinoid System · Hui‐Chen Lu · 2015 · 1249 citations · Cited by this paper
  14. Empirical-Null Calibration Challenges Comparative CNS Safety Signals for Androgen-Receptor Pathway Inhibitors: A FAERS Re-Analysis · 2026 · Related
  15. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia · Bryan L. Roth · 2004 · 1161 citations · Cited by this paper
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  19. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders · P. Jeffrey Conn · 2008 · 1063 citations · Cited by this paper
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  21. Cannabidiol is a negative allosteric modulator of the cannabinoid CB 1 receptor · Robert B. Laprairie · 2015 · 1044 citations · Cited by this paper
  22. Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes · Luciano De PETROCELLIS · 2010 · 952 citations · Cited by this paper
  23. Phytocannabinoids: a unified critical inventory · Lumír Ondřej Hanuš · 2016 · 863 citations · Cited by this paper
  24. Hormesis: The Dose-Response Revolution · Edward J. Calabrese · 2003 · 796 citations · Cited by this paper
  25. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies · Kerstin Iffland · 2017 · 648 citations · Cited by this paper
  26. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor · Ken Mackie · 1995 · 635 citations · Cited by this paper
  27. Molecular Targets of the Phytocannabinoids: A Complex Picture · Paula Morales · 2017 · 465 citations · Cited by this paper
  28. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex · Kaavya Krishna Kumar · 2019 · 457 citations · Cited by this paper
  29. Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability · Fabio Arturo Iannotti · 2014 · 418 citations · Cited by this paper
  30. Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs · Billy R. Martin · 1991 · 413 citations · Cited by this paper
  31. Inverse, protean, and ligand‐selective agonism: matters of receptor conformation · Terry Kenakin · 2001 · 410 citations · Cited by this paper
  32. Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour · Serena Deiana · 2011 · 410 citations · Cited by this paper
  33. Modulating the endocannabinoid system in human health and disease – successes and failures · Pál Pacher · 2013 · 408 citations · Cited by this paper
  34. Phytocannabinoids: Origins and Biosynthesis · Thies Gülck · 2020 · 402 citations · Cited by this paper
  35. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation · Jared C. Ehrhart · 2005 · 379 citations · Cited by this paper
  36. Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8 · Luciano De PETROCELLIS · 2008 · 340 citations · Cited by this paper
  37. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study · Estefanía Núñez · 2004 · 332 citations · Cited by this paper
  38. Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis · Dana C. Hammell · 2015 · 304 citations · Cited by this paper
  39. Pharmacologic Treatment of Severe Irritability and Problem Behaviors in Autism: A Systematic Review and Meta-analysis · Lawrence K. Fung · 2016 · 304 citations · Cited by this paper

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